박헌용 | 대학원 분자생물학과(천) (자연과학2관)
교수소개
단백질의 구조와 기능분석을 in vitro/ in vivo에서 수행하는 연구를 수행하고
있다. 주요 표적 단백질은 세포 신호전달물질이거나, 기능이 잘알려져 있지 않
은 단백질들로 새로운 기능탐색을 위한 단백질체학 혹은 유전체학적인 접근
을 병행하고 있다. 표적 단백질이 효소인 경우, 효소의 반응기작을 이해하기
위한 kinetic study와 단백질의 folding에 관한 기초연구를 Circular
Dichroism, Fluorescence, Calorimetry 를이용하여 연구하고 있다. 또한 신호
전달에 중요한 기능을 하고있는 단백질이 표적 단백질인 경우, 세포생물학적
접근법으로 신호전달경로의 새로운 이해와 그들을 이용한 질환의 병인과 치료
기반에 관한 정보를 획득하기위한 다양한 분자생물학적 접근법을 수행하고 있
다. 한편, 심혈관 생물학중에서 동맥경화와 관련이 있는 shear stress의 신호
전달과 shear stress의 생리적 효과에 관한 연구를 수행하고 있다. 이러한 연
구는 동맥경화의 원인규명과 치료에 많은 도움을 줄 것이다.
학력
- [1985] 학사 고려대학교 / 생물학 / 세포생물학
- [1996] 박사 Univ. of Tennessee - Knoxville / 생화학 / 생화학
주요연구분야
동맥경화 관련 연구
혈관형성 관련 연구
컨설팅 가능 분야
단백질 생산과 분리 정제기술의 개발
동물세포배양
연구업적
- 연구보고서[20101122] 전단응력 감지 XIAP 시그날로좀의 동맥경화 발생억제 작용기전 연구(2/2)
- 연구보고서[20070827] 서울 바이오 식품산업 혁신기술 네트워크 구축(3/3)
- 연구보고서[20060529] 서울 바이오 식품산업 혁신기술 네트워크 구축(2/3)
- 연구보고서[20040430] 암전이에 관여하는 shear stress 의존적 caveolae 신호전달경로(2/2)
- 연구보고서[20030709] 암전이에 관여하는 Shear stress 의존적 caveolac 신호전달경로(1/2)
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- 일반논문[20150706] Morphology-controlled Synthesis of Octahedral-to-Rhombic Dodecahedral Cu2O Microcrystals and Shape-dependent Antibacterial Activities
- 일반논문[20150706] Facet Effect of Ag3PO4 Crystals on Antibacterial Activities
- 일반논문[20150701] Extract from Prunus mume Sieb. et Zucc. Fruit Prevents LPS-induced Homotypic Aggregation of Monocytic THP-1 Cells via Suppression of Nitric Oxide Production and NF-κB Activation
- 일반논문[20150601] Angiogenic tube formation of bovine aortic endothelial cells grown on patterns formed by H2/He plasma treatment of the plasma polymerized hexamethyldisiloxane film
- 일반논문[20150430] 혈관내피세포에서 c-Jun N-terminal kinase에 의해 조절되는 세포사멸에 고농도의 피노실빈이 미치는 효과
- 일반논문[20141201] Pinosylvin at a high concentration induces AMPK-mediated autophagy for preventing necrosis in bovine aortic endothelial cells
- 일반논문[20140929] Disturbed flow enhances inflammatory signaling and atherosclerosis by increasing thioredoxin-1 level in endothelial cell nuclei
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- 일반논문[20140330] Bioactive surface modifications on inner walls of poly-tetra-fluoro-ethylene tubes using dielectric barrier discharge
- 일반논문[20140207] Mitsugumin 53 (MG53) Ligase Ubiquitinates Focal Adhesion Kinase during Skeletal Myogenesis
- 일반논문[20140101] Morphology-controlled synthesis of ZnO crystals with twinned structures and the morphology dependence of their antibacterial activities
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- 일반논문[20121101] H2S inhibits oscillatory shear stress-induced monocyte binding to endothelial cells Via nitric oxide production
- 일반논문[20120309] XIAP reverses various functional activities of FRNK in endothelial cells
- 일반논문[20120125] Lipid-binding properties of TRIM72
- 일반논문[20111020] Morphological Evolution of Ag(2)O Microstructures from Cubes to Octapods and Their Antibacterial Activities
- 일반논문[20110315] Morphology-dependent antibacterial activities of Cu2O
- 일반논문[20101201] Chunghyul-dan acts as an anti-inflammatory agent in endothelial cells by regulating gene expression
- 일반논문[20101101] Selective adhesion of intestinal epithelial cells on patterned films with amine functionalities formed by plasma enhanced chemical vapor deposition
- 일반논문[20100820] XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK
- 일반논문[20100805] X-linked inhibitor of apoptosis protein controls alpha(5)-integrin-mediated cell adhesion and migration
- 일반논문[20100701] Lycopene의 새로운 혈관내피세포 생리활성
- 일반논문[20100601] 혈관내피세포 탈착에 미치는 melatonin의 병리학적 영향
- 일반논문[20100115] A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential
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- 일반논문[20090601] Biochemical characterization of the lipid-binding properties of a broccoli cuticular wax-associated protein, WAX9D, and its application
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- 일반논문[20080912] Attachment and Growth of Bovine Aortic Endothelial Cells on Amine Surface Formed by Using Plasma-Enhanced Chemical-Vapor Deposition
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- 일반논문[20080425] X-Linked Inhibitor of Apoptosis Protein Is an Important Regulator of Vascular Endothelial Growth Factor Dependent Bovine Aortic Endothelial Cell Survival
- 일반논문[20080401] Frequent epigenetic inactivation of hSRBC in gastric cancer and its implication in attenuated p53 response to stresses
- 일반논문[20070915] Patterned amine surfaces with reduced background nonspecific protein adsorption fabricated by using inductively coupled plasma chemical vapor deposition
- 일반논문[20060930] Resveratrol-induced apoptosis is inhibited by nitric oxide in endothelial cells
- 일반논문[20060930] Unfolded Histidine-Tagged Protein is Immobilized to Nitrilotriacetic Acid-Nickel Beads, But Not the Nickel-Coated Glass Slide
- 일반논문[20060630] Caveolin-1 Is Associated with VCAM-1 Dependent Adhesion of Gastric Cancer Cells to Endothelial Cells
- 일반논문[20060615] Investigation of Protein Adsorption Using Plasma Treatment for Protein Chips
- 일반논문[20060331] Resveratrol at high doses acts as an apoptotic inducer in endothelial cells
- 일반논문[20060328] Role of PI3-Kinase/Akt Pathway in the Activation of Etoposide -Induced NF-kB Transcription Factor
- 일반논문[20060225] Physical properties of NiCl2 coated protein chip plates
- 일반논문[20060201] A new method for immobilization of lipid-binding proteins to the glass slides
- 일반논문[20060201] The patterned hydrophobic surfaces of glass slides to be applicable for the construction of protein chips
- 일반논문[20060120] Caveolin-1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase mu
- 일반논문[20050930] Identification of genes that are regulated by peroxisome proliferator activated reporter (PPAR)gamma activator, troglitazone during adipocyte differentiation
- 일반논문[20050601] Etoposide-induced apoptosis resistance by the PI3-kinase/Akt activated NF-kB p50 subunit
- 일반논문[20040830] Bovine Caveolin-2 Cloning and Effects of Shear Stress on Its Localization in Bovine Aortic Endothelial Cells
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- 일반논문[20040429] 단백질칩 기판의 표면에 미치는 용매효과
- 일반논문[20040301] Fibronectin-dependent cell adhesion is required for shear-dependent ERK activation
- 일반논문[20040201] Are Caveolae the Mechanosensing places in Endothelial Cells?
- 일반논문[20030901] Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells
- 일반논문[20030901] Structural characterization for N-terminal domain of caveolin-1
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- 일반논문[20030201] Protein immobilization on plasma-polymerized ethylenediamine-coated glass slides
- 일반논문[20021201] Protein Adsorption on the Nickel-Coated Glass Slide for Protein Chips
- 일반논문[20021121] SIGNALING PATHWAYS FOR TNF PRODUCTION INDUCED BY HUMAN AMINOACYL-tRNA SYNTHETASE-ASSOCIATING FACTOR, p43.
- 일반논문[20020901] Novel regulatory interactions and activities of mammalian tRNA synthetases.
- 일반논문[20020611] p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: Implications for its physiological significance.
- 일반논문[20020215] Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.
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- 일반논문[20011019] Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm.
- 일반논문[20011001] Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress.
- 일반논문[20010622] A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes
- 일반논문[20010401] Fas-induced expression of chemokines in human glioma cells: involvement of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase.
- 저서/역서[20080630] 건강기능식품
- 저서/역서[20060210] 생리학
- 지식재산권[20161007] 심혈관계 질환의 예방 및 치료를 위한 고농도 피노실빈 조성물(Pharmaceutical composition comprising Pinosylvin for preventing or treating cardiocascular diseases)
- 지식재산권[20151023] 피노실빈의 신규한 혈관신생촉진 용도
- 지식재산권[20150417] 오갈피 추출물을 유효성분으로 포함하는 혈관질환의 예방 또는 치료용 조성물(A composition for preventing or treating blood vessel disorders, comprising extracts of Acanthopanax)
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- 학술발표[20120816] Protective role of H2S in oscillatory shear stress-stimulated inflammatory signaling
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- 학술발표[20110818] TRIM 72의 분자결합에 관한 생화학적 특징
- 학술발표[20101228] Effect of Lycopene on Vascular Endothelial Cells
- 학술발표[20081029] A role of X-linked inhibitor of apoptotic proteins in Shear stress-stimulated activationof ERK in vascular endothelial cells
- 학술발표[20080821] A role of X-linked inhibitor of apoptotic proteins in vascular endothelial cells
- 학술발표[20080507] Charactrization of a broccoli non-specific lipid transfer protein,WAX9D, for lipid binding
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- 학술발표[20070528] Lysyl tRNA synthetase inhibits shear-stimulated nitric oxide production
- 학술발표[20070528] Vascular functions of x-linked inhibitor of apoptosis protein are associated with caveolin-1.
- 학술발표[20070528] Functional screening of chunghyul-dan in vascular endothelial cells.
- 학술발표[20061116] The X-linked inhibitor of apoptosis modulates vascular functions through its association with caveolin-1
- 학술발표[20060620] Patterned Protein Immobilization for High-Throughput Analysis
- 학술발표[20060526] Lipid-binding proteins immobilized to Nickel-coated glass slides are biologically active
- 학술발표[20060525] Lysyl tRNA synthetase binds to the surface of endothelial cells through sialic acids
- 학술발표[20060525] Lysyl tRNA synthetase inhibits shear stress-dependent activation of signaling molecules in endothelial cells
- 학술발표[20060519] Role of Lysyl tRNA synthetase in the shear stress-dependent signaling pathways
- 학술발표[20050519] VCAM-1 dependent adhesion is an important factor in gastric cancer
- 학술발표[20050125] Physical properties of Nicl2 coated protein chip plates
- 학술발표[20041023] Nickel chloride coated protein chip plate
- 학술발표[20040527] A deletion mutant of XIAP enhances the shear stress-dependent activation of ERK
- 학술발표[20040218] HIstidine-tagged protein immobilization on the nickel coated glass slide for the construction of protein chips.
- 학술발표[20040218] Protein Immobilization on the Amine-Coated Glass Slides Fabricated by Novel Methods.
- 학술발표[20030516] The role of integrins in the flow-dependent activation of ERK
- 학술발표[20020412] Unexpected new function of a known protein