일반대학원

• 학과소개
• 교수소개
• 교과과정

교수소개

내과, 특히 천식 및 알레르기질환에 대한 공부를 시작한 이후로 이들 질환의 임상상 및 알레르기염증반응의 기전에 대한 연구를 하고 있습니다. 알레르기 질환의 임상연구로서 국내에서는 처음으로 점박이응애가 알레르기 질환에 문제가 된다는 보고를 하였으며, 체계적이지 못했던 만성기침의 임상상을 정리하였었습니다. 알레르기질환 치료에 가장 중요한 스테로이드에 대한 기전연구와 함께 다양한 임상시험, 임상연구를 수행하고 있습니다.
약물 알레르기에 있어 유전적인 요인을 밝히는 약물유전체 사업에 8년째 책임연구원으로 참여하고 있으며 지속적인 성과를 얻어 이를 국내외에 발표하였습니다. 약물 유해반응에도 관심을 가지고 약물감시사업단과제를 수행하고 있으며 2007년부터 충청지역약물감시센터를 센터장으로 운영하고 있습니다.

학력

• [1987] 학사 서울대학교 / 의학 / 의학
• [1996] 석사 서울대학교 / 의학 / 약리학
• [2000] 박사 충북대학교 / 의학 / 내과학

주요연구분야

기관지천식 및 알레르기질환
알레르기 면역반응의 기전
약물알레르기
임상면역

연구업적

• 일반논문[20220901] Machine-learning algorithms for asthma, COPD, and lung cancer risk assessment using circulating microbial extracellular vesicle data and their application to assess dietary effects
• 일반논문[20220401] A new horizon of precision medicine: combination of the microbiome and extracellular vesicles
• 일반논문[20181114] The role of FGF-2 in smoke-induced emphysema and the therapeutic potential of recombinant FGF-2 in patients with COPD
• 일반논문[20181101] KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea
• 일반논문[20171101] Importance of indoor dust biological ultrafine particles in the pathogenesis of chronic inflammatory lung diseases
• 일반논문[20170701] CD8(+) T-cell activation by methazolamide causes methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis
• 일반논문[20160701] House Dust Mite-Derived Chitin Enhances Th2 Cell Response to Inhaled Allergens, Mainly via a TNF-alpha-Dependent Pathway
• 일반논문[20160501] IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer
• 일반논문[20160301] Staphylococcal enterotoxin IgE sensitization in late-onset severe eosinophilic asthma in the elderly
• 일반논문[20160201] 16S rRNA gene-based metagenomic analysis reveals differences in bacteria-derived extracellular vesicles in the urine of pregnant and non-pregnant women
• 일반논문[20151001] Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle
• 일반논문[20150901] Active Immunization with Extracellular Vesicles Derived from Staphylococcus aureus Effectively Protects against Staphylococcal Lung Infections, Mainly via Th1 Cell-Mediated Immunity
• 일반논문[20150401] Extracellular vesicles derived from gram-negative bacteria, such as Escherichia coli, induced emphysema mainly via IL-17A-mediated neutrophilic inflammation
• 일반논문[20150301] EVpedia: a community web portal for extracellular vesicles research
• 일반논문[20150101] Classification and implementation of asthma phenotypes in elderly patients
• 일반논문[20150101] Superoxide Dismutase Gene (SOD1, SOD2, and SOD3) Polymorphisms and Antituberculosis Drug-induced Hepatitis
• 일반논문[20140701] An Important Role of alpha-Hemolysin in Extracellular Vesicles on the Development of Atopic Dermatitis Induced by Staphylococcus aureus
• 일반논문[20140701] 천식 환자에서 재조합 Fibroblast growth factor 2의 안정성과 효능에 관한 전임상 연구
• 일반논문[20140401] Decreased diversity of nasal microbiota and their secreted extracellular vesicles in patients with chronic rhinosinusitis based on a metagenomic analysis
• 일반논문[20140201] An important role of tumor necrosis factor receptor-2 on natural killer T cells on the development of dsRNA-enhanced Th2 cell response to inhaled allergens
• 일반논문[20130630] 졸피뎀 유발 섬망의 발생률 및 위험요인
• 일반논문[20130401] Extracellular vesicles, especially derived from Gram-negative bacteria, in indoor dust induce neutrophilic pulmonary inflammation associated with both Th1 and Th17 cell responses
• 일반논문[20130301] Antituberculosis drug-induced hypersensitivity syndrome and its association with human leukocyte antigen
• 일반논문[20130130] Comorbid Diseases in Adult Asthma
• 일반논문[20120525] Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury
• 일반논문[20120501] TNF-alpha genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis
• 일반논문[20120330] Spontaneously Reported Hepatic Adverse Drug Events in Korea: Multicenter Study
• 일반논문[20120330] 반코마이신의 약물유해반응 분석 및 약물유해반응 보고의 활성화 방안
• 일반논문[20120229] A Clinical Study of Cutaneous Adverse Reactions to Nonionic Contrast Media in Korea
• 일반논문[20120101] Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs
• 일반논문[20111230] 기도상피세포에서 식물 에센셜 오일의 인터루킨-8 분비억제 효과
• 일반논문[20111230] 천식증상으로 내원한 성인에서 운동유발성 천식과 아토피의 상관관계
• 일반논문[20111101] Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans
• 일반논문[20110630] 기무라씨 병; 서혜부; 재발
• 일반논문[20110630] 일차진료의에서의 흡입기구 사용 숙련도 현황
• 일반논문[20110501] Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
• 일반논문[20110201] NAT2, CYP2C9, CYP2C19, and CYP2E1 genetic polymorphisms in anti-TB drug-induced maculopapular eruption
• 일반논문[20110125] Skills in handling turbuhaler, diskus, and pressurized metered-dose inhaler in korean asthmatic patients
• 일반논문[20110125] 페그-인터페론과 리바비린 병합치료 중 발생한 간질성 폐렴 및 범혈구 감소증 1예
• 일반논문[20100630] 기관지천식 치료의 최신 지견
• 일반논문[20100601] HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis
• 일반논문[20100225] A Case of Hypersensitivity to Mosquito Bite Associated with Epstein-Barr Viral Infection and Natural Killer Cell Lymphocytosis
• 일반논문[20100125] GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans
• 일반논문[20091225] Pharmacogenetic study of the effects of NK2R G231E G > A and TBX21 H33Q C > G polymorphisms on asthma control with inhaled corticosteroid treatment
• 일반논문[20091201] Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions
• 일반논문[20091130] Inappropriate Techniques Used by Internal Medicine Residents with Three Kinds of Inhalers (a Metered Dose Inhaler, Diskus, and Turbuhaler): Changes after a Single Teaching Session
• 일반논문[20091120] Genetic polymorphisms of drug-metabolizing enzymes and anti-TB drug-induced hepatitis
• 일반논문[20091001] Spontaneous reporting of adverse drug events by Korean Regional Pharmacovigilance Centers
• 일반논문[20090925] Development and Evaluation of an Asthma-Specific Quality of Life (A-QOL) Questionnaire
• 일반논문[20090825] Severe Asthma Patients in Korea Overestimate Their Adherence to Inhaled Corticosteroids
• 일반논문[20090530] Repression of TNF-alpha-induced IL-8 expression by the glucocorticoid receptor-beta involves inhibition of histone H4 acetylation
• 일반논문[20090425] Effect of beta 2-Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment
• 일반논문[20080101] The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylase
• 일반논문[20071101] 단기 항결핵 화학요법에 의한 약물 이상반응의 유병률
• 일반논문[20070625] 말초혈액단핵구에서 아토피에 따른 GATA-3, c-maf, T-bet의 발현차이
• 일반논문[20070401] Association between polymorphisms in prostanoid receptor genes and aspirin-intolerent asthma
• 일반논문[20070220] The effects of on-site measured ozone concentration on pulmonary function and symptoms of asthmatics
• 일반논문[20060625] 천식 환자의 말초혈액단핵구에서 아토피 유무에 따른 전사인자 T-bet 발현의 차이
• 일반논문[20060420] Association between sensitization to outdoor spider mites and clinical manifestations of asthma and rhinitis in the general population of adults
• 일반논문[20060325] 기도상피세포에서 formoterol과 budesonide 병합투여가 전사활성과 interleukin-8 분비에 미치는 영향
• 일반논문[20050411] Repression of IL-5 transcription by the glucocorticoid receptor targets GATA3 signalling and involves histone deacetylase recruitment
• 일반논문[20050130] Characterization of cigarette smoke extract (CSE)-induced cell death in lung epithelial cells
• 일반논문[20041125] Dexamethasone inhibits TRAIL- and anti-cancer drug-induced cell death in A549 cells inducing NF-kB-independent cIAP2 expression
• 일반논문[20040130] 아토피성 천식 환자의 말초혈액 단핵구에서 GATA-3와 T-bet의 mRNA 발현
• 일반논문[20030330] Inhibiting NF-kB activation by triptolide enhances TRAIL-induced cell death in lung cancer cells
• 일반논문[20021230] High prevalence of current asthma and active smoking effect among the elderly
• 일반논문[20020925] Role of environmental exposure to spider mites in the sensitization and the clinical manifestation of asthma and rhinitis in children and adolescents living in rural and urban areas
• 일반논문[20020625] 글루코코티코이드 수용체에 의한 전사억제 기전(종설)
• 일반논문[20010930] Suppression of Granucyte-Macrophage Colony-Stimulating Factor Expression by Glucocorticoids Involves Inhibition of Enhancer Function by the Glucocorticoid Receptor Binding to Composite NF-AT/Activator Protein-1 Elements
• 일반논문[20010401] Citrus red mite (panonychus citri) may be an important allergen in the development of asthma among exposed children
• 일반논문[20010130] 폐상피세포에서 Triptolide에 의한 NF-kB 의존성 IL-8 유전자 전사활성 억제기전
• 일반논문[20001225] 직업성천식 감시체계에 등록된 우리나라의 직업성천식 실태
• 일반논문[20000530] Two-spotted spider mite (Tetranychus urticae): an important allergen in asthmatic non-farmers symptomatic in summer and fall months
• 일반논문[19991225] 제주도 농촌지역 초등학생의 귤응애 항원에 대한 감작 현황과 귤응애에 대한 환경폭로가 감작에 미치는 영향
• 일반논문[19991201] Spider mite allergy in apple-cultivating farmers:European red mite (Panonychus ulmi) and two-spotted spider mite (Tetranychus urticae) may be important allergens in the development of work-related asthma and rhinitis symptoms
• 일반논문[19990825] 배과수원 주위 거주민에서 발생된 점박이응애에 의한 천식 1례
• 일반논문[19990801] Skin reactivity to inhalant allergens, total serum IgE levels, and bronchial responsiveness to methacholine are increased in parents of nonatopic asthmatic children
• 일반논문[19980630] 만성 기침으로 내원한 환자에서 원인 질환 및 빈도에 관한 전향적 연구
• 일반논문[19971125] 보행성 24시간 식도 pH 및 내압검사를 이용한 만성기침환자에서의 위식도 역류에 관한 연구
• 일반논문[19970725] Prevalence of childhood asthama based on questionnaires and methacholine bronchial provocation test in Korea
• 일반논문[19960925] 반응성염료에 의한 직업성 천식환자의 기관지 점막 병리 소견
• 저서/역서[20120330] 천식과 알레르기질환
• 학술발표[20130419] Escherichia coli-induced extracellular vesicles induce emphysema via both IFN-gamma- and IL-17-dependent pathways
• 학술발표[20121015] Bacteria-derived extracellular vesicles as an important causative agent for asthma and COPD
• 학술발표[20120526] Superoxide dismutase genes (SOD1, SOD2 and SOD3) polymorphisms
• 학술발표[20120526] Lack of association between genetic polymorphisms of IL-10 and TGF-b1
• 학술발표[20120525] Anaphylaxis in Korean adults: a multicenter retrospective case study
• 학술발표[20120525] Prospective study on correlation between inhaled corticosteroid adherence with various clinical factors in newly diagnosed Korean adult asthma patients
• 학술발표[20110603] TNF-alpha genetic polymorphism -308G/A and antituberculosis drugs-induced hepatitis
• 학술발표[20100529] The inhibitory effect of essential oils from citron, pine tree, chamaecyparis pisifera and chamaecyparis obtusa on IL-8 transcription and secretion
• 학술발표[20100528] Drug metabolizing enzymes (NAT2, CYP2C9, CYP2C19 and CYP2E1) gene polymorphisms and antituberculosis drugs induced maculopapular eruption
• 학술발표[20100528] The preclinical assessment of safety of recombinant FGF2 in patients with asthma
• 학술발표[20090508] Association between anti-tuberculosis drugs induced hepatitis and HLA alleles
• 학술발표[20090508] A Korean study of HLA in allopurinol induced severe cutaneous adverse reactions
• 학술발표[20090508] Anti-tuberculosis Drugs induced hypersensitivity syndrome; Clinical characteristics and association with HLA allele
• 학술발표[20090508] HLA genotypes in Korean patients with carbamazepine-induced severe cutaneous reaction
• 학술발표[20090508] GSTM1 and GSTT1 mutation and anti-tuberculosis drugs induced adverse reactions
• 학술발표[20060612] Personal exposure to ozone and changes of symptoms and lung function in asthmatics
• 학술발표[20060531] Mechanisms of glucocorticoid receptor and functional role of glucocorticoid receptor beta
• 학술발표[20060513] The effects of on-site measured ozone concentration on pulmonary function and respiratory symptoms of asthmatics
• 학술발표[20060513] Cysteinyl leukotriene receptor 1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients
• 학술발표[20060513] Association between genetic polymorphisms of prostanoid receptors and aspirin-intolerant asthma
• 학술발표[20060512] Multicenter study with internet-based database on the drug hypersensitivity reactions in Korea
• 학술발표[20051008] 만성두드러기 질환의 진단 및 치료: 증례별 토의
• 학술발표[20050631] The total expression of T-bet in the peripheral blood mononuclear cells is important in asthmatic status and the sources of cell type is determined by atopic status
• 학술발표[20050611] 새로이 보고된 직업성 천식: 그 임상적 특성 및 병인기전
• 학술발표[20050318] Prevalence of adverse drug reactions to anti-tuberculosis drugs in Korea
• 학술발표[20041005] Molecular mechanisms of glucocorticoid receptor in the suppression of Th2 sytokines
• 학술발표[20041005] Expression of GATA-3 and T-bet in the peripheral blood mononuclear cells according to atopic status
• 학술발표[20021015] Transcriptional repression of cytokine genes by GR
• 학술발표[20021014] Represion of Interleukin-5 Transcription by the Glucocorticoid Receptor Involves Recruitment of Histone Deacetylases
• 학술발표[20020503] Association between sensitization to outdoor spider mites adn the prevalence of asthma and rhinitis symptoms for exposed children and adolescents