일반대학원

• 학과소개
• 교수소개
• 교과과정

교수소개

본인은 대학원 석,박사 과정에서 발생 면역, 발생공학, 세포생물학 분야에서
세포주기 분야를 연구하였고, 박사후 연구원 시절에는 암 분자생물학 분야를
연구하였읍니다. 귀국후 LG 생명과학 연구원의 책임연구원으로 재직하며
연구분야를 기초연구에서 응용연구로 확장시키며, 항암제, 항감염제 등의
신약개발 연구를 수행하였읍니다.
현재는 간 질환 연구를 수행하고 있으며, 특별히 간 섬유화 분야의 연구에
집중하고있읍니다. 이와 동시에 독특한 난자 기반 항암제 분석 시스템을
개발하여 항암제 발굴 연구도 동시에 수행하고있읍니다.

주요연구분야

세포기반 신약 스트리닝

컨설팅 가능 분야

난자의 초기발생분야, 형질전환 마우스 제작, 간질환 동물 모델,
항암제 스크리닝, 세포 기반 스크리닝 시스템 등

연구업적

• 일반논문[20230101] Effects of mastication on antibody production under fasting conditions in mice
• 일반논문[20200301] Quantitative changes innatural antibodies stimulated from a D-galactose-induced aging mouse model
• 일반논문[20180901] Evaluating the Immunological Adjuvant Activities of Carrageenan and Degraded Carrageenan
• 일반논문[20161001] Splenocyte proliferation and anaphylaxis induced by BSA challenge in a D-galactose-induced aging mouse model
• 일반논문[20160401] Subcutaneous administration of monosodium glutamate to pregnant mice reduces weight gain in pups during lactation
• 일반논문[20150401] The production of cross-reactive autoantibodies that bind to bovine serum albumin in mice administrated reducing sugars by subcutaneous injection
• 일반논문[20140113] Production of cross-reactive autoantibody binding to bovine serum albumin in the D-galactose-induced aging mouse model
• 일반논문[20121102] polycystic ovary syndrome (PCOS)-like phenotypes in the D-galactose-induced aging mouse model
• 일반논문[20111230] Effect of MLN8237, a novel Aurora A kinase inhibitor, on the spontaneous fragmentation of ovulated mouse oocytes
• 일반논문[20110501] Dimethyl sulfoxide inhibits spontaneous oocyte fragmentation and delays inactivation of maturation promoting factor (MPF) during the polonged culture of ovulated murine oocytes in vitro
• 일반논문[20100330] Co-treatment with Demecolcine and BMI-1026, a Potent cdk1 Inhibitor, Induces the Enucleation of Murine Oocytes
• 일반논문[20091230] Corelation between oocyte spontaneous volume decrease and fragmentation
• 일반논문[20080927] Isolation of embryonic stem cells from enhanced green fluorescent protein-transgenic mouse and their survival in the cochlea after allotransplantation
• 일반논문[20080731] Effect of various factors on early THP-1 dell adhesion induced PMA.
• 일반논문[20071203] Bone marrow derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice
• 일반논문[20070630] Effect of BMI-1026, a potent CDK inhibitor, on murine oocyte maturation and metaphase II arrest
• 일반논문[20070302] Angiogenic role of LYVE-1-positive macrophages in adipose tissue
• 일반논문[20060331] 다약제 내성 Acinetobacter균의 유전종 결정 및 항균제 내성의 특성 규명(Determination of Genomospecies and Characterization of antimicrobial resistance of multi-drug resistant Acinetobacter spp. isolates)
• 일반논문[20050501] Oocyte-based screening of cytokinesis inhibitors and identification ofpectenotoxin-2 that induces Bim/Bax-mediated apoptosis in p53-deficient tumors
• 일반논문[20041201] Oocyte-based screening system for anti-microtubule agents
• 일반논문[20040930] 마우스 난 성숙과정에서의 Thymeleatoxin의 영향
• 일반논문[20040423] Bcl-XL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senesence by preventing reactive oxygen species-dependent p38 activation
• 일반논문[20040401] A phenotypic study of murine oocyte death in vivo
• 일반논문[20040331] CCI₄로 유발된 마우스의 실험적 급성간염 모델에서 종간에 따른 자연발생적 간염치유속도에 관한 비교 연구(The study of the spontaneous recovery time in acute hepatitis induced by CCl4 in three mouse strains)
• 일반논문[20040330] 자생식물 추출물의 세표 분산 활성(Cell scattering activity of natural plant extracts)
• 일반논문[20031103] 마우스 배란난의 in vitro 세포 사 연구
• 일반논문[20030919] cdk2 dependent phoshorulation of the NF-Y transcription Factor and its involvement in the p53-p21 Signaling pathway
• 일반논문[20011201] A novel Class highly potent, selective, and Non-peptidic inhibitor Of Ras Farnesyltransferase(Ftase)
• 일반논문[20011101] p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor
• 일반논문[19990101] The regulatory Mechanism of Meiotic cell cycle.
• 일반논문[19970819] CENP-E is and essential kinetochore motor in maturing oocytes and is masked during Mos-dependent, cell cycle arrest at metaphase II
• 일반논문[19970605] A novel human ERK phosphatase regulates H-ras and V-raf signal transduction.
• 일반논문[19960709] The Mos/mitogen-activated protein kinase (MAPK) pathway regulates the size and degradation of the first polar body in maturing mouse oocytes.
• 일반논문[19960322] Abnormal centrosome amplification in the absence of p53
• 일반논문[19960314] Mos/mitogen-activated protein kinase can induce early meiotic phenotypes in the absence of maturation-promoting factor: a novel system for analyzing spindle formation during meiosis. I.
• 일반논문[19920601] Direct activation of p34cdc2 protein kinase without preceeding phosphorylation during meiotic cell cycle in mouse oocytes
• 일반논문[19911101] Activation of p34cdc2 protein kinase activity in meiotic and mitotic cell cycles in mouse oocytes and embryos.
• 일반논문[19870301] Benificial effect of serum on the fertilizability of mouse oocyte maturation in vitro
• 저서/역서[20040228] 세포 분자 면역학(Cellular and Molecular Immunology)
• 지식재산권[20080519] Pharmaceutical composition comprising praziquantel, a derivative thereof and salt thereof
• 지식재산권[20070207] 프라지콴텔, 또는 이의 염을 포함하는 약학 조성물
• 지식재산권[20060412] 장구채 추출물을 포함하는 간 기능개선 및 감 질환 치료용 조성물
• 지식재산권[20051117] Rani의 세포사멸조절제로서의 신규한 용도(출원)
• 지식재산권[20050825] FK506을 이용한 세포의 노화를 억제하는 방법 및 배양배지
• 지식재산권[20050825] 사이클로스포린A 또는 이의 유도치를 이용한 세포의 노화를 억제하는 방법및 배양배지
• 지식재산권[20040903] 산삼 배양근 추출물을 함유하는 간 섬유화 치료용 조성물
• 학술발표[20090912] Trophoblast cells from mouse induced pluripotent stem cell (mouse iPS)
• 학술발표[20050518] Effect of a potent cdk1 inhibitor on GVBD and metaphase arrest of mouse oocytes
• 학술발표[20040605] The study of the spontaneous recovery time in acute hepatitis induced by ccl4 in three mouse strains
• 학술발표[20031215] Oocyte-based screening system of antimicrotubule agents
• 학술발표[20031009] Phosphorylation of the NF-Y transcription factor by cdk2 and its involvement in cell cycle progression through the G1/S and G2/M transition
• 학술발표[20031009] Loss of p53 function sensitizes cells to actin inhibitor through induction of cdk-dependent mitochondrial translocation of Bax
• 학술발표[20031009] Bcl-XL and E1B-19K proteins inhibit p53-induced irreversible growth arrest and senesence by preventing ROS-dependent p38 activation
• 학술발표[20030613] 마우스 미수정란의 난관내 세포사 관련 연구