일반대학원

• 학과소개
• 교수소개
• 교과과정

교수소개

신경퇴행과정(neurodegenerative processes)에 관심을 갖고 연구하고 있습니다. 퇴행성 신경질환의 초기에 발생되는 시냅스 손상은 HIV-1 관련 치매(HIV-1 associated dementia)나 알츠하이머병(Alzheimer’ disease)을 겪는 환자에서 인지능력이 감퇴되는 현상과 잘 연관되어 있으며, 세포 사멸 과정에서 발생되는 초기 현상이 아니라 과도한 흥분성 자극으로 부터 세포를 보호할 수 있는 독립적 기전임을 발표한 바 있습니다. 앞으로 진행할 후속연구들은 시냅스 접점수의 변화가 정서장애로부터의 안정을 유도하는 데 기반이 되는 기전을 알아보고, 퇴행성 신경질환을 보호, 치료할 수 있는 방법을 모색하고자 합니다.

학력

• [2005] 박사 가톨릭대학교(성의교정) / 의학과 생리학전공

주요경력

• 가톨릭대학교 의과대학 (2001-01-01)
• University of Minnesota Medical School (2005-03-01)
• University of Minnesota Medical School (2009-10-19)

주요연구분야

Drug Abuse
Neuron-glia signaling mechanisms
Neurodegnerative diseases
Neuroprotective mechanism
Regulation of synaptogenesis and synaptic transmission

컨설팅 가능 분야

Neurophysiology, Neurodegenerative diseases (dementia), Synapse, Neurotoxicity

연구업적

• 일반논문[20231101] Regeneration of taste through sonic hedgehog upregulation by photobiomodulation
• 일반논문[20230802] Alleviation of hippocampal necroptosis and neuroinflammation by NecroX-7 treatment after acute seizures
• 일반논문[20230726] Cognitive training based on functional near-infrared spectroscopy neurofeedback for the elderly with mild cognitive impairment: a preliminary study
• 일반논문[20230101] Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3
• 일반논문[20221201] Immunofluorescent Distribution of SIRT1, SIRT2, SIRT6 Protein in the Skin of SKH1 Mouse after Ultraviolet B Irradiation for 10 Weeks
• 일반논문[20220822] Maternal lead exposure induces sex-dependent cerebellar glial alterations and repetitive behaviors
• 일반논문[20220201] Synapto-protective effect of lithium on HIV-1 Tat-induced synapse loss in rat hippocampal cultures
• 일반논문[20210901] Sex-related Differences in Glial Fibrillary Acidic Protein-positive GABA Regulate Neuropathology Following Pilocarpine-induced Status Epilepticus
• 일반논문[20210801] Truncated Neogenin Promotes Hippocampal Neuronal Death after Acute Seizure
• 일반논문[20210501] Exposure to RF-EMF Alters Postsynaptic Structure and Hinders Neurite Outgrowth in Developing Hippocampal Neurons of Early Postnatal Mice
• 일반논문[20171101] The Ginsenoside Derivative 20(S)-Protopanaxadiol Inhibits Solar Ultraviolet Light-Induced Matrix Metalloproteinase-1 Expression
• 일반논문[20170801] The co-expression of Neogenin with SOX2 in hippocampal neurons
• 일반논문[20170801] Characterization and optical properties of TeO2/ZnO nanocomposites synthesized in a narrow temperature range
• 일반논문[20170601] Dapoxetine induces neuroprotective effects against glutamate-induced neuronal cell death by inhibiting calcium signaling and mitochondrial depolarization in cultured rat hippocampal neurons
• 일반논문[20170301] Usage of Human Mesenchymal Stem Cells in Cell-based Therapy: Advantages and Disadvantages
• 일반논문[20170101] Neuroprotective effect of lithium after pilocarpine-induced status epilepticus in mice
• 일반논문[20160601] One-to-One Correspondence Growth Mechanism of Gourd-like SiOx Nanotubes
• 일반논문[20160501] Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity
• 일반논문[20160101] Brief low [Mg2+]o-induced Ca2+ spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons
• 일반논문[20130115] Fluoxetine suppresses synaptically induced [Ca2+](i) spikes and excitotoxicity in cultured rat hippocampal neurons
• 일반논문[20120901] Synapse Loss Induced by Interleukin-1beta Requires Pre- and Post-Synaptic Mechanisms
• 일반논문[20120601] Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat
• 일반논문[20111101] Sustained Fos expression is observed in the developing brainstem auditory circuits of kanamycin-treated rats
• 일반논문[20110901] Activation of Cannabinoid Type 2 Receptors Inhibits HIV-1 Envelope Glycoprotein gp120-Induced Synapse Loss
• 일반논문[20110801] Grape seed proanthocyanidin extract inhibits glutamate-induced cell death through inhibition of calcium signals and nitric oxide formation in cultured rat hippocampal neurons
• 일반논문[20090501] Lithium Increases Synapse Formation between Hippocampal Neurons by Depleting Phosphoinositides
• 일반논문[20081101] Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death
• 일반논문[20080601] Cannabinoids inhibit network-driven synapse loss between hippocampal neurons in culture
• 일반논문[20080101] Excitotoxic loss of post-synaptic sites is distinct temporally and mechanistically from neuronal death
• 일반논문[20070101] Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
• 일반논문[20061001] Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway
• 일반논문[20060901] Desensitization of somatostatin-induced inhibition of low extracellular magnesium concentration-induced calcium spikes in cultured rat hippocampal neurons
• 일반논문[20050801] Fluoxetine inhibits ATP-induced [Ca2+](i) increase in PC12 cells by inhibiting both extracellular Ca2+ influx and Ca2+ release from intracellular stores
• 일반논문[20040201] Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores
• 일반논문[20030601] Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells
• 일반논문[20020701] Bone-protecting effect of safflower seeds in ovariectomized rats
• 지식재산권[20220304] 뇌전증에 의해 유발된 뇌손상 진단용 마커로서의 네오제닌의 용도
• 지식재산권[20201230] 다폭세틴을 유효성분으로 포함하는 뇌전증지속증의 예방 또는 치료용 조성물
• 지식재산권[20201223] 신경 발달 장애의 발병 위험도 예측용 바이오마커 조성물
• 지식재산권[20200423] 헤르바세틴을 유효성분으로 포함하는 뇌전증지속증 또는 신경퇴행 예방 또는 치료용 조성물
• 지식재산권[20200304] 네오제닌을 포함하는 신경 줄기세포능 유지 및 신경 줄기세포 증식 촉진용 배지 조성물 및 이를 이용한 방법(Culture media composition for promoting neuronal stem cell proliferation and maintaining neuronal stem cell capacity comprising neogenin)
• 지식재산권[20180612] 네오제닌을 포함하는 신경 줄기세포능 유지 및 신경 줄기세포 증식 촉진용 배 지 조성물 및 이를 이용한 방법
• 지식재산권[20170222] 3,3''-다이인돌일메탄, 이의 전구체인 인돌-3-카르비놀 또는 이들의 혼합물을 포함하는 간질중첩증 예방 또는 치료용 약학적 조성물
• 지식재산권[20151218] 3,3'-다이인돌일메탄, 이의 전구체인 인돌-3-카르비놀 또는 이들의 혼합물을 포함하는 간질중첩증 예방 또는 치료용 약학적 조성물
• 학술발표[20150813] Neuroprotective Effect of Lithium on HIV-1 Tat-induced Loss of Synapse between Rat Hippocampal Neurons
• 학술발표[20150813] Neuroprotective Effect of 3,3'-diindolylmethane on the Loss of Synapse Following Pilocarpine-induced Status Epilepticus
• 학술발표[20150521] Neuroprotective Effect of 3,3'-diindolylmethane on the Loss of Synapse Following Pilocarpine-induced Status Epilepticus
• 학술발표[20150521] Neuroprotective Effect of Lithium on HIV-1 Tat-induced Loss of Synapse between Rat Hippocampal Neurons
• 학술발표[20130913] Mood stabilizer regulates neuritogenesis in rat hippocampal neurons
• 학술발표[20121025] Pharmacologic Modulation of Synapse Loss in an in vitro Model of Neurodegenerative Disease
• 학술발표[20120717] Effects of mood stabilizer on synapse between rat hippocampal neurons in culture
• 학술발표[20101210] Cannabinoids inhibit gp120-induced synapse loss
• 학술발표[20101028] Activation of CB2 Cannabinoid Receptors Inhibits gp120-induced Synapse Loss