일반대학원

• 학과소개
• 교수소개
• 교과과정

교수소개

1985년에 서울대학교 자연과학대학 동물학과 (현 생명과학부)에서 이학사를 받은 후 도미하여 1990년에 미국 유타대학교 의과대학에서 생화학 및 분자생물학으로 이학박사를 취득하였다. 1990년도 부터 1993년까지 미국 스탠포드대학교 의과대학 발생생물학과에서 박사후 연구원으로 활동하면서 RNA와 단백질의 상호작용및 세포내 이동에 관한 연구를 수행하였다. 귀국후 서울대학교 유전공학연구소에서 면역세포의 발생과 분화 관련 유전자와 신호전달관련 연구를 수행하였다. 1995년도에 단국대학교 분자생물학과에 부임한 후, 분자생물학과 학과장과 국제교류처 처장 등을 역임하였다.

1997년도 부터 분자세포생물학 실험실을 운영하며 암세포 형성과정에 중요하게 작동하는 RNA 신호전달 방법을 기반으로 한 신개념 항암제를 개발하고 있다. 단국대 부임이후 다수의 국가연구과제를 수행하여, 2007년도에는 과학기술부 국가연구개발 우수성과 100선와 학술진흥재단 우수성과 51선에 선정된 바 있다. 특히 "BK21 RNA 전문인력양성사업팀"의 사업팀장을 맡았고, 교육과학기술부 선정 "국가지정연구실(NRL)"의 책임자로도 활동하였다. 2007년도와 2014년도에 단국대 범은학술상을 수상하였고, 2014년도에는 한국 로레알-UNESCO 여성생명과학상 학술진흥상을 수상한 바 있다. 국제적 우수연구자 집단인 F1000의 chemical biology 의 국내 유일한 faculty member 이기도 하다.

한국 RNA 학회 회장과 한국분자세포생물학회 뉴스지편집위원장 및 출판위원장, 여성생명과학기술포럼 총무위원장, 한국여성과학기술단체 총연합회 총무이사를 역임하였고, 현재는 분자세포생물학회 학술상위원회 위원장, 학회 공식 SCI 학회지 부편집장, 대통령 직속 국가생명윤리심의위원회 위원으로 활동하고 있다.

학력

• [1985] 학사 서울대학교 / 동물생명과학전공 / 세포생물학
• [1990] 박사 University of Utah / 생화학과 / 세포생물학

주요경력

• 스탠포드대학교 (1990-12-01)
• 서울대학교 유전공학연구소 (1994-03-01)

주요연구분야

Aptamer sensor 개발
Peptide aptamer 개발
RNA aptamer 개발
면역 조절제 개발
면역세포 신호전달 및 발생과정
심혈관 질환 조절제 개발
암세포 특이적 RNA 발현 기전
유전자 치료
항암제 개발

컨설팅 가능 분야

암세포 형성 및 사멸 조절 방안
면역 이상 기능 조절 방안
RNA Aptamer 개발

연구업적

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• 연구보고서[20090528] 암세포 특이적 RNA 네트워크 발굴및 제어 기술(1/5)
• 연구보고서[20090429] 세포암화 및 밤낮주기조절에서의 RNA decay 조절 기전 연구(3/3)
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• 연구보고서[20080219] 암 표적화 기술소재 개발 및 검증(3/3)
• 연구보고서[20080115] 세포암화 및 밤낮주기조절에서의 RNA decay 조절 기전 연구(2/3)
• 연구보고서[20070312] Beta-catenin에 의한 RNA alternative Splicing에 대한 연구(1/2)
• 연구보고서[20070228] 세포암화 및 밤낮주기조절에서의 RNA decay 조절 기전 연구(1/3)
• 연구보고서[20070227] 암 표적화 기술소재 개발 및 검증(2/3)
• 연구보고서[20070224] 심혈관질환 진단 및 치료를 위한 펩타이드 앱타머 개발
• 연구보고서[20060630] Beta-catenin에 의한 세포암화 조절 및 신개념 RNA 조절 네트워크 탐색(2차년도)
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• 연구보고서[20051121] 바이오 분석칩을 위한 aptamer 개발
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• 연구보고서[20040224] 나노바이오칩에 응용을 위한 Aptamer 기술개발(1/2)
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• 연구보고서[20030315] MCP-1에 결합하여 기능을 저해하는 펩타이드의 개발(1/2)
• 연구보고서[20020630] 대학.학부 및 전공별 특성화 위원회 연구
• 연구보고서[19990420] 핵산라이브러리를 이용한 세포접합 차단제의 개발
• 연구보고서[19981130] T세포의 apoptosis 유도에 따른 TCF-1 유전자 발현의 조절에 관한 연구-2
• 연구보고서[19971125] T세포의 apoptosis 유도에 따른 TCF-1 유전자 발현의 조절에 관한 연구-1
• 연구보고서[19961220] T세포 분화과정에 있어서의 TCF-1유전자 발현조절에 의한 세포의 죽음에 관한 연구
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• 일반논문[20061101] Preferentially enhanced gene expression from a synthetic human telomerase reverse transcriptase promoter in human cancer cells.
• 일반논문[20060901] Intracellular expression of the T-cell factor-1 RNA aptamer as an intramer
• 일반논문[20060519] Suppression of Receptor-mediated Apoptosis by Death effecter domain Recruiting Domain Binding Peptide Aptamer,
• 일반논문[20060328] Role of PI3-kinase/Akt pathway on the activation of etoposide-induced NF-kB transcription factor
• 일반논문[20051031] PI3-kinase and PDK-1 regulate HDAC1-mediated transcriptional repression of transcription factor NF-kB
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• 학술발표[20031010] Reciprocal Repression of NF-κB and β-catenin/TCF Transcription Factors
• 학술발표[20031010] In Vitro Selection of RNA Aptamers for β-catenin /TCFProtein Interaction as a Specific Targeting Molecule
• 학술발표[20031010] RNA intramer specifically modulates the β-catenin-mediated transcription and the protein-protein interaction in the colon cancer cells
• 학술발표[20031010] Activation of Akt pathway in Response to Etoposide leads to Phosphorylation of p50 Subunit of NF-kB
• 학술발표[20031010] Specific Regulation of MCP-1 Functions by the Peptide Aptamer against the Monocyte Chemoattractant Protein (MCP-1)
• 학술발표[20031010] In vitro Characterization and Intracellular Expression of the Nucleocapsid Protein Binding RNA Aptame
• 학술발표[20030710] Specific modulation of Wnt signaling by the b-catenin binding RNA intramer
• 학술발표[20030514] Searching for high affinity ligands employing mix-and-match library: NC-binding RNA aptamer as a model system
• 학술발표[20030514] Cross-talk between transcription factors for the regulation of signaling network
• 학술발표[20030514] In vitro selection of the RNA aptamer to the b-catenin binding domain of Tcf protein
• 학술발표[20030430] RNA aptamer as a specific modulator of Wnt signaling mediated carcinogenesis
• 학술발표[20021107] Modulation of Wnt/β-catenin signaling by the armadillo domain binding RNA aptamer
• 학술발표[20021017] Etoposide-induced activation of the NFkB transcription factor via the PI3K/Akt pathway
• 학술발표[20021017] Specific regulation of the TCF-1 (T-cell factor-1) transcription factor by the HMG domain binding RNA aptamer
• 학술발표[20021017] Specific modulation of the receptor-mediated apoptosis by the intracellular expressed peptide aptamer to the FLASH protein
• 학술발표[20021017] Stabilization of the HIV-1 nucleocapsid binding RNA aptamer by circularization and by intramer expression
• 학술발표[20021017] Modulation of the anti-DNA autoantibody by the in vitro selected RNA aptamer
• 학술발표[20021017] Specific peptide aptamer for the MCP-1 as a regulator for the atherosclerosis
• 학술발표[20020314] Specific detection of the cancer cell surface sugar antigen with the peptide and RNA aptamers
• 학술발표[20011011] Inhibition of Wnt Signaling by the RNA Aptamers against the β-catenin and TCF Proteins
• 학술발표[20011011] Suppression of the Etoposide-Induced Apoptosis by the Activation of the Tcf Transcription Factor
• 학술발표[20011011] Development of the Packaging Inhibitor by RNA Aptamers against the Nucleocapsid Protein of HIV-1
• 학술발표[20011011] Development of Apoptosis Modulating RNA and Peptide Aptamers
• 학술발표[20011011] Mimicry of Tandem Repeat Peptides against Sialy1 Lewis X
• 학술발표[20010603] A prototype retargeted adenoviral vector interacting with a tumor antigen Sialyl Lewis X
• 학술발표[20001018] Development of TCF-1 binding RNA as a tool for the regulation of transcription activity of TCF-1/beta-catenin complex in the cells
• 학술발표[20001013] Development of sialyl Lewis X binding RNA and peptides as specific inhibitors of cell adhesion
• 학술발표[20001013] RNA aptamer for HIV-1 nucleocapsid as a specific and high affinity inhibitor of nucleocapsid protein/psi RNA binding in vivo
• 학술발표[20000924] Development of RNA aptamers which bind to the pathogenic molecules of immune cells
• 학술발표[19991025] Development of the immunoregulratory therapy utilizing the RNA combinatorial library
• 학술발표[19991025] Development of Trans-splicing ribozyme targeted to the tumor suppressor gene
• 학술발표[19991025] In vitro selection of RNA aptamer which has nanomolar binding affinity to anti-DNA autoantibody from MRL/lpr autoimmune mouse model for SLE
• 학술발표[19991025] In vitro selected RNA aptamer specifically binds to sialyl Lewis X sugar moiety and inhibits selectin/ligand adsorption of HL60 cells
• 학술발표[19990430] Protein-RNA interaction analysis using Biosensor
• 학술발표[19990221] Glycosidase Antibodies Using in Vivo and In Vitro Immunization
• 학술발표[19990208] In Vitro Selection of RNA for Biologically Interesting Small Molecules and Evaluation of Binding via Surface Plasmon Resonance
• 학술발표[19981024] Selection of High Affinity RNA Binder to the Carbohydrate Molecule from the Combinatorial RNA Library
• 학술발표[19981024] Reduction of Tcf-1 Expression is Responsible for the Down-Modulation of TCR/CD3 Complex during T-cell Apoptosis
• 학술발표[19980425] In Vitro Selection of Sialyl-Lewis X Specific RNA Molecules
• 학술발표[19980418] Down-regulation of Tcf-1 and surface TCR/CD3 Complex during Apoptosis of T-cell
• 학술발표[19971215] Expression of murine Tcf-1 gene is specifically reduced during calcium-ionophore induced apotosis of
• 학술발표[19971018] Expression of murine Tcf-1 gene is Specifically reduced during apoptosis of T-cell hybridoma
• 학술발표[19961026] Down Regulation of TCF-1 & CD3-e Expression durings apoptosis in T-cell Hybridoma
• 학술발표[19960509] Preparation of antibodies with glycosidase activity using in vitro and in vivo immunizations
• 학술발표[19951020] Expression of CD3 and TCF-1 during apoptosis induced in T-cell hybridoma.
• 학술발표[19920604] Expression of RNAse MRP RNA during Xenopus development.
• 학술발표[19920527] Identification of the RNase MRP activity: Isolation of the RNA component and its abundance during de
• 학술발표[19890707] Tests of the Double-strand-break repair recombination and other models of homologous recombination i
• 학술발표[19890320] The effect of terminal nonhomology on homologous recombination in Xenopus laevis oocytes.