이성욱 사진

이성욱 | 대학원 생명융합공학과 (소프트웨어 ICT관)

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    교수

교수소개

1985년 서울대학교 미생물학과를 졸업하고 1987년 동대학원에서 석사학위를 받았으며 1995년 미국 Cornell 대학 분자생물학과에서 박사학위를 취득하였다. 학위논문의 주제는 RNA를 이용한 HIV의 유전자 치료법 개발이다. 학위 후에는 1994년부터 3년간 Duke 의과대학에서 박사후 연구과정을 거쳤다. 연구과제는 RNA를 이용한 자가면역질환 치료제 개발 및 유전병에 대한 유전자 치료법 개발이었으며 특히 RNA를 이용한 치료제 개발은 신개념의 치료제로서 그 결과가 세계적인 생명공학지인 Nature Biotechnology의 1997년 1월호의 표지에 소개되었다.

1997년 본교 자연과학부 분자생물학 전공교수로 부임하였고, 2016년 2학기부터 대학원 생명융합학과 교수로 재직하고 있다. 2003년부터 2009년까지 교내 부설 연구소인 나노센서 바이오텍 연구소 소장을 겸임하였으며, 2014년부터 현재까지 교내 부설연구소인 차세대오믹스 연구소소 소장을 겸임하고 있다. 2017년 8월 교내지주회사 자회사인 바이오벤처기업 알지노믹스(주)를 창업하여 현재 대표이사를 겸직하고 있다.

주관심사 및 현재 연구하는 주요 분야는 유전질환, 종양 및 퇴행성 질환 그리고 바이러스성 질환 등 현재 난치병으로 알려진 여러 인체질환에 대한 RNA를 기반으로 한 신개념의 치료제 개발과 유전자 치료법 개발연구 그리고 새로운 진단법 개발이다. 특히 새로운 유전자 치료제로서 Trans-splicing ribozyme의 개발을 미국 연구진과 공동연구하여 그 결과를 1998년 세계적인 과학저널인 Science에 발표하는 개가를 올렸으며, 2012년도에는 대장암의 간전이를 억제하는 핵산 aptamer를 개발하여 소화기학분야의 최고 권위지인 Gastroenterology 지 해당 이슈의 주요논문으로 발표하였다. 2007년, 2012년, 2014년 범은학술상을 수상하였으며, 2013년 한국연구재단애서 수여하는 기초연구 우수성과 50선에 선정되었으며 2015년 보건복지부 장관 표창상을 수상하였다..

2009년부터 2013년까지 한국핵산학회 부회장, 회장을 역임하였으며, 2019년부터 현재까지 한국유전자세포치료학회 회장을 역임하고 있다. 현재 국제 올리고핵산치료학회의 공식 저명학술지인 Nucleic Acid Therapeutics 및 미국 유전자세포치료학회와 Cell Press에서 발간하는 Molecular Therapy: Nucleic Acid 등 총 8개 국제 학술지의 편집위원으로 활동하고 있다.

학력

  • [1985] 학사 서울대학교 / 미생물학
  • [1987] 석사 서울대학교 / 미생물학
  • [1995] 박사 Cornell Univ. / 분자생물학과 / 분자유전학

주요연구분야

RNA 기반 암 및 바이러스 질환 치료 및 진단제 개발
RNA 특성 및 기능 연구
게놈 기능 유전학 연구
암 및 바이러스 질환 진단법 개발

컨설팅 가능 분야

유전자치료법 개발. RNA 기능 연구. RNA aptamer 탐색 및 응용 연구.
Ribozyme 연구, Riboswitch 개발 및 응용연구, C형 간염바이러스 복제기전 및 관련 질환, 암유전자치료

연구업적

  • 연구보고서[20121022] 마이크로 RNA 조절을 통한 암특이적 RNA 치환 기반 암 유전자 치료(3/3)
  • 연구보고서[20120611] Chimeric RNA bi-aptamer 기반 C형 간염바이러스 증식억제 연구(2/2)
  • 연구보고서[20111130] Human T cell specific RNAi-based therapetic nano-medicine for AIDS(3/3)
  • 연구보고서[20110831] 세포 특이적 압타머 선별 기법 개발을 통한 고성능 암진단용 압타머 컨텐츠 발굴(3/3)
  • 연구보고서[20110228] 나노기반의 압타머 활용기술을 통한 위해성 평가 시스템 개발(3/3)
  • 연구보고서[20110222] Allosteric trnas-splicing ribozyme의 개발을 통한 표적특이적이며 조절가능한 유전자 치료기술 연구[3단계(3/3)]
  • 연구보고서[20101118] hybrid RNA 기반 암세포 특이적 siRNA 전달체 개발 연구(2/2)
  • 연구보고서[20101031] 바이오링커용 앱타머 제작
  • 연구보고서[20100428] Aptazyme 기반 RNA간섭 조절을 통한 C형 간염바이러스 증식 억제 연구(2/2)
  • 연구보고서[20091130] Human T cell specific RNAi-based therapetic nano-medicine for AIDS(1/3)
  • 연구보고서[20090930] 세포 특이적 압타머 선별 기법 개발을 통한 고성능 암진단용 압타머 컨텐츠 발굴(1/3)
  • 연구보고서[20090918] hybrid RNA 기반 암세포 특이적 siRNA 전달체 개발 연구(1/2)
  • 연구보고서[20090223] Aptazyme 기반 RNA간섭 조절을 통한 C형 간염바이러스 증식 억제 연구(1/2)
  • 연구보고서[20090223] Allosteric trnas-splicing ribozyme의 개발을 통한 표적특이적이며 조절가능한 유전자 치료기술 연구[2단계(1/3)]
  • 연구보고서[20081130] RNA aptamer에 의한 암태아성 항원 유도성 암전이 제어 연구
  • 연구보고서[20081031] 식품위해요소 검출용 앱타머 기술개발(2차년도)
  • 연구보고서[20080731] MicroRNA 발현 조절을 통한 C형 간염바이러스 증식 억제 연구
  • 연구보고서[20080225] Allosteric trnas-splicing ribozyme의 개발을 통한 표적특이적이며 조절가능한 유전자 치료기술 연구(3/3)
  • 연구보고서[20071105] 돌연변이 Ras RNA의 특이적 치환을 통한 암유전자 치료법 개발(3차년도)
  • 연구보고서[20070630] CKAP2 RNA의 특이적 표적 및 치환을 통한 종양 치료법 개발(3/3)
  • 연구보고서[20070306] Allosteric trnas-splicing ribozyme의 개발을 통한 표적특이적이며 조절가능한 유전자 치료기술 연구(2/3)
  • 연구보고서[20060623] 돌연변이 Ras RNA의 특이적 치환을 통한 암유전자 치료법 개발(2차년도)
  • 연구보고서[20060224] Allosteric trnas-splicing ribozyme의 개발을 통한 표적특이적이며 조절가능한 유전자 치료기술 연구(1/3)
  • 연구보고서[20050801] 돌연변이 Ras RNA의 특이적 치환을 통한 암유전자 치료법 개발
  • 연구보고서[20050713] CKAP2 RNA의 특이적 표적및 치환을 통한 종양 치료법 개발(1/3)
  • 연구보고서[20050527] 선택적으로 세포사 활성을 유도하는 trans-splicing ribozyme의 조직 특이적 발현을 통한 특이적 암 유전자치료법 연구(2/2)
  • 연구보고서[20040329] 선택적으로 세포사 활성을 유도하는 trans-splicing ribozyme의 조직 특이적 발현을 통한 특이적 암 유전자치료법 연구(1/2)
  • 연구보고서[20031230] 단백질과의 결합을 고려한 RNA 구조 예측 및 이를 이용한 신약 탐색
  • 연구보고서[20030731] 국가의 기초과학육성과 정보화사회의 신지식인 교육을 위한 유연교육시스템 개발
  • 연구보고서[20021226] Dendritic cell-based Tumor Vaccines에 의한 암 특이적 면역 유도 반응 및 확인
  • 연구보고서[20021031] 단백질과의 결합을 고려한 RNA 구조 예측 및 이를 이용한 신약 탐색
  • 연구보고서[20020331] Telomerase 유전자 전사체를 특이적으로 치환하는 trans-splicing ribozyme 개발을 통한 암 유전자 치료법 연구
  • 연구보고서[20011130] 유용 aptamer들의 생산 및 특성 연구
  • 연구보고서[20010525] 남성 불임 유전자 Rbm의 기능 연구
  • 연구보고서[20000918] 표적유전자 전사체의 재프로그램을 유발하는 trans-splicing ribozyme을 이용한 C형 간염바이러스 감염질환에 대한 유전자 치료법 개발
  • 연구보고서[20000417] 자가면역질병 환자의 자가항체반응을 억제하는 RNA 분자의 분리 및 분석
  • 연구보고서[19981127] Development of trans-splicing ribozymes for the gene therapy of genetic diseases
  • 일반논문[20231219] Adenovirus VA RNAs impair maturation of primary microRNA
  • 일반논문[20231214] Generation of hepatitis C virus-resistant liver cells by genome editing-mediated stable expression of RNA aptamer
  • 일반논문[20230912] Efficient circular RNA engineering by end-to-end self-targeting and splicing reaction using Tetrahymena group I intron ribozyme
  • 일반논문[20230911] Real-time monitoring strategies for optimization of in vitro transcription and quality control of RNA
  • 일반논문[20221101] Pros and Cons of In Vitro Methods for Circular RNA Preparation
  • 일반논문[20220512] Therapeutic Application of Genome Editing Technologies in Viral Diseases
  • 일반논문[20210417] Aptamers for Anti-Viral Therapeutics and Diagnostics
  • 일반논문[20210305] Targeted suicide gene therapy for liver cancer based on ribozyme-mediated RNA replacement through post-transcriptional regulation
  • 일반논문[20200208] Small Animal PET Imaging of hTERT RNA-Targeted HSV1-tk Gene Expression with Trans-Splicing Ribozyme
  • 일반논문[20190925] A novel strategy for interpreting the T-SPOT. TB test results read by an ELISPOT plate imager
  • 일반논문[20190801] Enhancement of chemosensitivity in 5‑fluorouracil‑resistant colon cancer cells with carcinoembryonic antigen‑specific RNA aptamer
  • 일반논문[20190301] Exosomal transmission of microRNA from HCV replicating cells stimulates transdifferentiation in hepatic stellate cells
  • 일반논문[20181201] Group I Intron-Based Therapeutics Through Trans-Splicing Reaction
  • 일반논문[20180501] Therapeutic applications of group I intron-based trans-splicing ribozymes
  • 일반논문[20180215] Development of RNA aptamer that inhibits methyltransferase activity of dengue virus
  • 일반논문[20170601] Effects of Human Mesenchymal Stem Cells Coculture on Calcium-Induced Differentiation of Normal Human Keratinocytes
  • 일반논문[20170515] The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches
  • 일반논문[20170501] The role of microRNA in pathogenesis and as markers of HCV chronic infection
  • 일반논문[20170129] Inhibition of Japanese encephalitis virus (JEV) replication by specific RNA aptamer against JEV methyltransferase
  • 일반논문[20170126] Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement
  • 일반논문[20161101] Genotyping of 19 red cell antigens, including RHD, using liquid bead arrays
  • 일반논문[20160701] Hepatitis C virus infection stimulates transforming growth factor-β1 expression through up-regulating miR-192
  • 일반논문[20160201] Therapeutic Applications of Aptamer-Based Riboswitches
  • 일반논문[20160106] Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma
  • 일반논문[20151006] Pharmacokinetics of a Cholesterol-conjugated Aptamer Against the Hepatitis C Virus (HCV) NS5B Protein
  • 일반논문[20150801] Targeting the MicroRNA Passenger Strand for Regulating Therapeutic Transgenes
  • 일반논문[20150720] Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation
  • 일반논문[20150320] Recombinant adenovirus infection suppresses hTERT expression through virus-associated RNA-mediated induction of type 1 interferon
  • 일반논문[20150128] Targeted anticancer effect through microRNA-181a regulated tumor-specific hTERT replacement
  • 일반논문[20141220] Selective expression of transgene using hypoxia-inducibletrans-splicing group I intron ribozyme
  • 일반논문[20141121] Conditional and Target-Specific Transgene Induction through RNA Replacement Using an Allosteric Trans-Splicing Ribozyme
  • 일반논문[20140601] The Role of MicroRNAs in Hepatitis C Virus Replication and Related Liver Diseases
  • 일반논문[20140601] In vitro selection of RNA aptamers that selectively bind danofloxacin
  • 일반논문[20140523] In vitro selection of RNA aptamer specific to Staphylococcus aureus
  • 일반논문[20140328] Efficient targeting and tumor retardation effect of pancreatic adenocarcinoma up-regulated factor (PAUF)-specific RNA replacement in pancreatic cancer mouse model
  • 일반논문[20140101] Use of tumor-targeting trans-splicing ribozyme for cancer treatment
  • 일반논문[20131220] Colony forming assay for HCV-replicon cell line
  • 일반논문[20131201] Prospects for nucleic acid-based therapeutics against hepatitis C virus
  • 일반논문[20131116] Aptamers as therapeutic agents against hepatitis C virus
  • 일반논문[20130628] In vitro selection of RNA aptamer specific to Salmonella Typhimirium
  • 일반논문[20130601] Inhibition of Hepatitis C Virus (HCV) Replication by Specific RNA Aptamers against HCV NS5B RNA Replicase
  • 일반논문[20130401] Induced Degradation of Tat by Nucleocapsid (NC) via the Proteasome Pathway and Its Effect on HIV Transcription
  • 일반논문[20130401] Carbon Nanotube-Patterned Surface-Based Recognition of Carcinoembryonic Antigens in Tumor Cells for Cancer Diagnosis
  • 일반논문[20120731] Rapid Detection of Food Pathogens Using RNA Aptamers-Immobilized Slide
  • 일반논문[20120701] An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice
  • 일반논문[20120331] Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme
  • 일반논문[20120328] Cancer-specific induction of adenoviral E1A expression by group I intron-based trans-splicing ribozyme
  • 일반논문[20120201] Hepatitis C Virus Replication-Specific Inhibition of MicroRNA Activity with Self-Cleavable Allosteric Ribozyme
  • 일반논문[20120106] Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein
  • 일반논문[20120106] In vitro selection of Escherichia coli O157:H7-specific RNA aptamer
  • 일반논문[20111115] In vivo target specificity of hCKAP2-replacing trans-splicing ribozyme
  • 일반논문[20110815] Selective and efficient retardation of cancers expressing cytoskeleton-associated protein 2 by targeted RNA replacement
  • 일반논문[20110228] Intracellular efficacy of tumor-targeting group I intron-based trans-splicing ribozyme
  • 일반논문[20101201] Selection of peptides binding to HCV E2 and inhibiting viral infectivity
  • 일반논문[20101122] Accurate trans-splicing reaction in vivo by hCKAP2-targeting group I intron ribozyme
  • 일반논문[20100901] Comparative analysis of intracellular inhibition of hepatitis C virus replication by small interfering RNAs
  • 일반논문[20100623] Identification of RNA Aptamer Specific to Mutant KRAS Protein
  • 일반논문[20100412] In vivo reprogramming of human telomerase reverse transcriptase (hTERT) by trans-splicing ribozyme to target tumor cells
  • 일반논문[20100301] Selection of RNA aptamers specific to active prostate-specific antigen
  • 일반논문[20091231] RNA Mapping of Mutant Myotonic Dystrophy Protein Kinase 3’-Untranslated Region Transcripts
  • 일반논문[20090930] Sequence and Structural Features of RNA Aptamer Against Myasthenic Autoantibodies
  • 일반논문[20090930] Trans-splicing reaction in cells by mTERT-targeting group I intron
  • 일반논문[20090901] RNA aptamer-based sensitive detection of SARS coronavirus nucleocapsid protein
  • 일반논문[20090901] Cancer Cell Targeting with Mouse TERT-Specific Group I Intron of Tetrahymena thermophila
  • 일반논문[20090201] Validation of tissue-specific promoter-driven tumor-targeting trans-splicing ribozyme system as a multifunctional cancer gene therapy device in vivo
  • 일반논문[20090116] hnRNP L is required for the translation mediated by HCV IRES
  • 일반논문[20080930] Development of trans-splicing aptazyme which can specifically modify hepatitis C virus genome.
  • 일반논문[20080930] Inhibition of telomerase expression in vivo by hTERT targeting trans -splicing ribozyme
  • 일반논문[20080630] In vivo target RNA specificity of trans-splicing phenomena by the group I intron
  • 일반논문[20080101] In vivo reprogramming of hTERT by trans-splicing ribozyme to target tumor cell
  • 일반논문[20080101] Antitumor effects of systemically delivered adenovirus harboring trans-splicing ribozyme in intrahepatic colon cancer mouse model.
  • 일반논문[20071231] Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme
  • 일반논문[20071127] Molecular imaging of endogenous mRNA expression in mouse tumor model by adenovirus harboring trans-splicing ribozyme
  • 일반논문[20070930] Development of hepatitis C virus (HCV) genome-targeting hammerhead ribozyme which activity can be allosterically regulated by HCV NS5B RNA replicase
  • 일반논문[20070528] Expression and purification of recombinant active prostate-specific antigen from Escherichia coli.
  • 일반논문[20070510] Targeted retardation of hepatocarcinoma cells by specific replacement of alpha-fetoprotein RNA
  • 일반논문[20070430] Selective regression of cells expressing mouse cytoskeleton-associated protein 2 transcript by trans-splicing ribozyme
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  • 일반논문[20040801] Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA
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  • 지식재산권[20171214] TERT 프로모터 돌연변이에 특이적인 CRISPR 시스템 및 그의 이용
  • 지식재산권[20171214] CRISPR 시스템 기능 향상 방법 및 그의 이용
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  • 지식재산권[20170703] 키메릭 항원 수용체(Chimeric antigen receptor) 전달용 CTLA-4 타겟팅 트랜스-스플라이싱 라이보자임 및 이의 용도(CTLA-4 targeting trans-splicing ribozyme for delivering chimeric antigen receptor and use thereof)
  • 지식재산권[20170427] 암 특이적 트랜스-스플라이싱 라이보자임 및 이의 용도 (CANCER SPECIFIC-SPLICING RIBOZYME AND USE THEREOF)
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  • 지식재산권[20170329] 암 특이적 트랜스-스플라이싱 라이보자임 및 이의 용도 (CANCER SPECIFIC-SPLICING RIBOZYME AND USE THEREOF)
  • 지식재산권[20170224] 암 특이적 트랜스-스플라이싱 라이보자임 및 이의 용도(Tumor-targeting trans-splicing ribozyme and use thereof)
  • 지식재산권[20161118] C형 간염 바이러스의 코어 부위를 표적으로 하는 트랜스-스플라이싱 라이보자임 및 이의 용도
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  • 지식재산권[20161018] 뎅기바이러스 혈청형 2 및 3의 메틸트랜스퍼라제 활성을 억제하는 RNA
  • 지식재산권[20161005] 신규한 RNA 앱타머 및 그의 용도
  • 지식재산권[20160913] 재조합 간암세포주를 이용하여 다양한 레벨의 miR-122 발현을 조절하는 방법
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  • 지식재산권[20150217] 치료 유전자의 선택적 발현을 위한 DNA 구조체
  • 지식재산권[20150202] 키메릭 항원 수용체(Chimeric antigen receptor) 전달용 CTLA-4 타겟팅 트랜스-스플라이싱 라이보자임 및 이의 용도
  • 지식재산권[20150106] RNA aptamer specifically binding to carcinoembryonic antigen and use thereof
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  • 지식재산권[20141211] Aptazyme Capable of Selective Silencing of Target miRNA by Releasing an Antisense Sequence in Hepatitis C Virus-Infected Cells and Use Thereof
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  • 지식재산권[20140219] Allosteric trans-splicing group I ribozyme whose activity of target-specific RNA replacement is controlled by theophylline
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  • 지식재산권[20100317] RNA Aptamer Specifically Binding to Carcinoembryonic Antigen and Use thereof
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  • 지식재산권[20080327] 테오필린에 의해 표적 특이적 RNA 치환 활성이 조절되는 알로스테릭 트랜스-스플라이싱 그룹 I 리보자임
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  • 지식재산권[20070104] 씨이에이의 암 전이 유도 도메인에 특이적으로 결합하는알엔에이 압타머
  • 지식재산권[20050512] 씨형 간염 바이러스의 아이알이에스 발현 세포에서만 선택적으로 유전자 활성을 유도하는 트랜스-스플라이싱 리보자임
  • 지식재산권[20050118] 엔에프에이티씨에 특이적으로 결합하는 알엔에이
  • 지식재산권[20030625] C형 간염 바이러스 증식조절단백질에 특이적으로 결합하는 RNA 및 이를 이용한 HCV 감염 진단용 키트
  • 지식재산권[20020611] 아미노-RNA에 대한 항체 및 이의 제조방법
  • 학술발표[20191015] Targeted RNA relacement/repair as an emerging therapeutic strategy
  • 학술발표[20181109] Exosomal transmission of miR-192 from HCV-infected cells induces transdifferentiation in hepatic stellate cells
  • 학술발표[20181109] Group-I intron ribozyme based RNA reprogramming as an effective approach for cancer theranostics
  • 학술발표[20181109] Diverse application of Carcinoembryonic Antigen specific RNA aptamer as a cancer therapeutic tool
  • 학술발표[20180916] Interplay between Factors for RNA Metabolism Regulates HCV Replication
  • 학술발표[20171104] In vitro selection of RNA aptamers against dengue virus methyltransferase as anti-DENV agent
  • 학술발표[20171103] Down-regulation of exosomal miRNAs represses HCV-induced liver fibrosis through deactivation of hepatic stellate cells
  • 학술발표[20171103] Multifunction of Carcinoembryonic Antigen specific RNA aptamer as a cancer therapeutic tool
  • 학술발표[20170916] Exosome-Mediated microRNA Transmission in HCV-Induced Liver Fibrosis
  • 학술발표[20160923] Group I Intron-based RNA Reprogramming for Cancer Theranostics
  • 학술발표[20151127] Specific delivery of anti-cancer siRNA via CEA aptamer-siRNA chimeras to CEA expressing cancer cells
  • 학술발표[20151127] Pharmacokinetics of a cholesterol-conjugated aptamer targeting the hepatitis C virus (HCV) NS5B protein
  • 학술발표[20151127] Hepatitis C virus induced IFNA2 gene inhibits viral replication by core-specific trans-splicing ribozyme
  • 학술발표[20151127] Efficient tumor regression through regulated derivatives of group I-based trans-splicing ribozyme
  • 학술발표[20151127] Targeting miR-192 for the inhibition of HCV-induced liver fibrogenesis
  • 학술발표[20151127] Enhancement of anticancer chemosensitivity by carcinoembryonic antigen specific RNA aptamer
  • 학술발표[20150630] Targted anticancer strategy through microRNA-regulated tumor-specific RNA
  • 학술발표[20150629] MIR-192 as potential target of HCV-induced liver fibrogenesis.
  • 학술발표[20150629] Development of regulated derivatives of group I-based trans-splicing ribozyme for cancer gene therapy
  • 학술발표[20150629] Carcinoembryonic antigen specific RNA aptamer as multimodal anticancer tools.
  • 학술발표[20150629] Development of specific RNA aptamer against Japanese encephalitis virus methyltransferase
  • 학술발표[20150625] Role of microRNAs in hepatitis C virus replication and related pathogenesis
  • 학술발표[20150513] Targeted anticancer approach through microRNA-regulated Tumor-specific RNA replacement
  • 학술발표[20150113] Conditional and target-specific transgene induction through RNA replacement using an allosteric trans-splicing ribozyme
  • 학술발표[20141024] Developmet of cancer gene therapy based on cancer-specific RNA replacement through microRNA regulation
  • 학술발표[20141024] Adenoviral vector system inhibiting VA RNA for pri-miRNA delivery
  • 학술발표[20141024] Development of regulated derivatives of group I-based trans-splicing ribozyme for cancer gene therapy
  • 학술발표[20141019] RNA aptamer specific to Japanese encephalitis virus methyltransferase as anti-viral agent
  • 학술발표[20141019] Multifuctional RNA aptamers as intracellular decoys or molecular sensors for HCV therapeutics
  • 학술발표[20141018] RNA-based therapeutics against liver metastasis of colon cancer
  • 학술발표[20141010] Multiple use of RNA aptamers as intracellular decoys or molecular sensors for HCV therapeutics
  • 학술발표[20141010] Development of regulated derivatives of group I-based trans-splicing ribozyme for cancer gene therapy
  • 학술발표[20141010] Reduction of chemoresistance by carcinoembryonic antigen specific RNA aptamer in colon cancer
  • 학술발표[20141010] Development of RNA aptamer specific to Japanese encephalitis virus methyltransferase as a therapeutic agent
  • 학술발표[20141010] Adenoviral vector system for pri-miRNA delivery through VA RNA inhibition
  • 학술발표[20140501] Inhibition of HCV replication with HCV NS5B specific RNA aptamer
  • 학술발표[20140314] RNA aptamers for therapeutics against hepatitis C virus
  • 학술발표[20140228] RNA-based therapeutics against liver metastasis of colon cancer
  • 학술발표[20140202] Apllication of miRNA passenger strand with miRNA activity
  • 학술발표[20140202] Impaired maturation of primary microRNA by adenovirus VA RNA
  • 학술발표[20131130] RNA-based therapeutics against hepatic metastasis of colon cancer
  • 학술발표[20131122] Inhibition of hepatitis C virus replication using RNA aptamer against HCV NS5B replicase
  • 학술발표[20131122] CEA specific RNA aptamer-mediated chemoresistancy reduction and therapeutic application
  • 학술발표[20131122] Development of RNA aptamer against JEV methyltransferase as antiviral agent
  • 학술발표[20131122] Anti-tumor enhancement by modification of trans-splicing ribozyme
  • 학술발표[20131011] Overview of emerging technologies in nucleic acid-based therapeutics
  • 학술발표[20131006] In vitro selection of RNA aptamers which specifically bind to Japanese Encephalitis Virus methyltransferase
  • 학술발표[20131006] Therapeutic application of carcinoembryonic antigen specific RNA aptamer in colon cancer
  • 학술발표[20131005] RNA aptamers as intracellular decoys or molecular sensors for HCV therapetuics
  • 학술발표[20131005] Enhancement of chemosensitivity in colon cancer cells by RNA aptamer specific to carcinoemryonic antigen
  • 학술발표[20131005] RNA aptamers as antiviral against Japanese Encephalitis virus
  • 학술발표[20130831] RNA aptamers for anti-viral therapeutics
  • 학술발표[20130624] Induction of chemosensitivity in 5-FU resistant cancer cells by CEA specific RNA aptamer
  • 학술발표[20130624] In vitro selection of RNA aptamer specific to Japanese Encephalitis virus methyltransferase
  • 학술발표[20130624] Specific and efficient cancer regression with tran-splicing ribozyme targeting KRASV12 RNA
  • 학술발표[20130515] Refinement of adenovirus harboring trans-splicing ribozyme targeting hepatocellular carcinoma
  • 학술발표[20130515] Inhibition of hepatitis C virus replication using HCV dependent miR-122 silencing allosteric ribozyme
  • 학술발표[20130213] RNA aptamer specific to the metastasis-inducing domain of carcinoembryonic antigen
  • 학술발표[20121123] Anti-cancer therapy based on the cancer-specific gene induction by microRNA regulation
  • 학술발표[20121123] Trans-splicing ribozyme that can specifically regress cancer cells expressing Kras G12V
  • 학술발표[20121108] Development of RNA aptamers against food-borne pathogen bacteria
  • 학술발표[20121012] RNA aptamer targeting carcinoembryonic antigen prevents hepatic metastasis of colon cancer cells in mice
  • 학술발표[20121011] Downregulation of microRNA by adenovirus infection
  • 학술발표[20121010] RNA-based gene therapeutic agents against hepatic metastasis of colon cancer
  • 학술발표[20121010] Identification of RNA aptamer that specifically binds to the cold shock domain of Lin28 protein
  • 학술발표[20120704] RNA aptamer targeting carcinoembryonic antigen prevents hepatic metastasis of colon cancer cells
  • 학술발표[20120703] Studies on the improvement of efficacy of trans-splicing ribozyme for cancer therapy based on group I intron of Tetrahymena thermophila
  • 학술발표[20120703] Development of therapeutic RNA aptamer against HCV NS5B replicase
  • 학술발표[20120601] Role of host small RNAs in hepatitis C virus replication
  • 학술발표[20111125] Hepatocarcinoma specific regression through microRNA-122-regulated RNA replacement
  • 학술발표[20111125] Enhancement of efficacy of group I intron-based trans-splicing ribozyme for cancer therapy
  • 학술발표[20111125] Inhibition of miR-122 functions specifically in HCV-replicating cells
  • 학술발표[20111125] Modulation of colon cancer through ectopic expression of miR-192
  • 학술발표[20111125] Anti-cancer approach based on the cancer-specific RNA replacement by microRNA regulation
  • 학술발표[20111031] Optimization of group I intron-based trans-splicing ribozyme for cancer therapy
  • 학술발표[20111031] Antiviral aptamer
  • 학술발표[20111031] Liver specific anti-cancer approach through microRNA-122-regulated RNA replacement
  • 학술발표[20111031] Ectopic expression of miR-122 for the modulation of colon cancer
  • 학술발표[20111007] Enhancement of efficacy of trans-splicing ribozyme based on group I intron of Tetrahymena thermophila
  • 학술발표[20111006] Genetic system inhibiting miR-122 function specifically in HCV-replicating cells.
  • 학술발표[20111006] Modulation of colon cancer through miR-192 expression.
  • 학술발표[20111006] Cancer gene therapy based on the cancer-specific RNA replacement by microRNA regulation.
  • 학술발표[20111006] Specific and efficient regression of hepatocarcinoma through trans-splicing ribozyme regulated by MicroRNA-122
  • 학술발표[20110908] Allosteric ribozyme capable of specifically inhibiting miR-122 functions through HCV NS5B protein sensing
  • 학술발표[20110908] Anti-cancer approach through microRNA-regulated RNA replacement.
  • 학술발표[20110822] HCV replicating cell specific inhibition of miR-122 function using HCV NS5B sensing allosteric ribozyme
  • 학술발표[20110615] Development of Japanese Eencephalitic Virus methyltransferase specific RNA aptamers for anti-viral agent
  • 학술발표[20110615] Allosteric ribozyme capable of specifically inhibiting miR-122 finctions only in HCV replicating cells
  • 학술발표[20110613] Targeted RNA replacement by Trans-splicing ribozyme for cancer modulation
  • 학술발표[20110428] RNA 앱타머를 이용한 식품유해세균 신속 검출 연구
  • 학술발표[20101201] Aptamers for antiviral agents
  • 학술발표[20101130] RNA aptamer as inhibitor against CEA-inducing hepatitis
  • 학술발표[20101130] Identification and characterization of specific RNA aptamer to danofloxacin
  • 학술발표[20101130] Therapeutic application of HCV NS5B protein specific RNA aptamers
  • 학술발표[20101130] In vitro selection of high affinity RNA aptamer to Lin28 and Lin28B
  • 학술발표[20101130] Development of RNA aptamer targeting Japanese Encephalitis Virus (JEV) methyltransferase as anti-JEV therapeutic agent
  • 학술발표[20101126] 앱타머 기반 식품위해요소 검출용 리간드 개발
  • 학술발표[20101119] Administration route for more efficacy and safety during HCC-selective gene therapy with adenovirus harboring cancer-targeting trans-splicing ribozyme and liver-specific promoters in vivo
  • 학술발표[20101119] Development of cancer gene therapy based on the cancer-specific gene induction through microRNA regulation
  • 학술발표[20101119] Therapeutic approach with allosteric ribozymes which release HCV genome targeting siRNA
  • 학술발표[20101119] Cancer gene therapy with regulated trans-splicing ribozyme by microRNA
  • 학술발표[20101119] Utility value of miRNA passenger strand in miRNA pathway
  • 학술발표[20101022] Liver cancer-specific gene induction through microRNA regulation.
  • 학술발표[20101022] Development of JEV MTase specific RNA aptamers for therapeutic agent
  • 학술발표[20101022] Utility of miRNA passenger strand in miRNA pathway
  • 학술발표[20101022] Specific targeted gene replacement by microRNA
  • 학술발표[20101008] Availability of miRNA passenger strand in miRNA pathway
  • 학술발표[20101008] Development of anti-viral RNA aptamer to Japanese encephalitis virus methytransferase
  • 학술발표[20101008] Development of allosteric hammerhead ribozyme which release HCV genome targeting siRNA
  • 학술발표[20101008] Inhibition of hepatitis C virus replication using HCV NS5B specific RNA aptamers
  • 학술발표[20101008] RNA aptamer as a therapeutic leads for cea-inducing hepatic metastasis
  • 학술발표[20101008] Development of RNA aptamers against Lin28 and Lin28B protein which inhibit let-7miRNA family processing
  • 학술발표[20101008] Development of specific RNA aptamers to danofloxacin
  • 학술발표[20101008] Cancer gene therapy based on the cancer-specific RNA replacement of through microRNA regulation
  • 학술발표[20101008] Specific cancer cell regression with trans-splicing ribozyme which can be specifically regulated by microRNA
  • 학술발표[20100911] RNA aptamer against HCV NS5B protein for its therapeutic application
  • 학술발표[20100824] Therapeutic potential of HCV NS5B protein specific RNA aptamer
  • 학술발표[20100803] RNA aptamer as an agent against HCV replication
  • 학술발표[20100611] RNA aptamer for cancer therapy and molecular imaging
  • 학술발표[20100521] Specific and efficacious RNA aptamer against hepatic metastasis of colon cancer
  • 학술발표[20100208] Trans-splicing ribozyme for cancer therapy and moleuclar imaging
  • 학술발표[20091127] RNA-based cancer gene therapy with trans-splicing ribozyme which can expression can be specifically regulated by microRNA
  • 학술발표[20091127] Biological activity of microRNA passenger strand in microRNA function
  • 학술발표[20091109] RNA aptamer as a potent inhibitor against hepatic metastasis of colon cancer
  • 학술발표[20091109] Development of specific RNA aptamer to JEV Methyltransferase as anit-viral therapeutic agent
  • 학술발표[20091109] RNA aptamers against infectious diseases
  • 학술발표[20091109] miRNA inhibition using differently localized Pol Ⅲ promoter-based anti-miR expression system
  • 학술발표[20091109] Regulatory activity of microRNA passenger strand
  • 학술발표[20091104] Vector-based antimiR expression system which inhibits miRNA function
  • 학술발표[20091104] Role of microRNA passenger strand in microRNA function
  • 학술발표[20091104] RNA-based cancer therapy with trans-splicing ribozyme which expression can be specifically regulated by microRNA
  • 학술발표[20091104] RNA aptamer as a potent therapeutic lead for hepatic metastasis
  • 학술발표[20091104] Development of anti-JEV RNA aptamers
  • 학술발표[20091015] RNA aptamer as an anti-HCV agent
  • 학술발표[20091004] Inhibition of hepatitis C virus replication using NS5B-specific RNA aptamers
  • 학술발표[20090825] Trans-splicing ribozyme specifically reprogramming K-RASV12 transcript for cancer therapy
  • 학술발표[20090824] RNA aptamer that efficiently prevents intrahepatic metastasis of colon cancer
  • 학술발표[20090710] Trans-splicing ribozyme as theragnostic agent against cancer
  • 학술발표[20090613] Specific cancer cell regrsssion with trans-splicing ribozyme which can be specifically regulated by microRNA
  • 학술발표[20090612] Putative role of microRNA passenger strand in microRNA pathway
  • 학술발표[20090611] Liver cancer-specific gene induction through microRNA regulation
  • 학술발표[20090426] miRNA inhibition using vector-based anti-miR expression system
  • 학술발표[20090401] RNA aptamer as an inhibitor against hepatic metastasis of colon cancer
  • 학술발표[20090216] Inhibition of hepatic metastasis of colon cancer using RNA aptamer
  • 학술발표[20081128] Trans-splicing ribozyme-based cancer gene therapy
  • 학술발표[20081128] Isolation and characterization of RNA aptamers specific to JEV methyltransferase.
  • 학술발표[20081128] Allosteric hammerhead ribozyme which activity can be specifically regulated by HCV NS5B protein
  • 학술발표[20081128] RNA aptamer as an efficient agent suppressing carcinoembryonic antigen inducing hepatic metastasis of colon cancer.
  • 학술발표[20081128] Cancer gene therapy with K-RASV12 RNA-reprogramming trans-splicing ribozyme.
  • 학술발표[20081128] Allosteric trans-splicing ribozyme as target-specific and exogenously controllable gene therapeutic agent.
  • 학술발표[20081128] Development of endogenously controllable RNA interference approach
  • 학술발표[20081030] Ligand-controlled aptazyme as regulator of transgene expression through modulation of RNA processing
  • 학술발표[20081017] RNA aptamer as an efficient inhibitor against CEA-inducing hepatic metastasis
  • 학술발표[20081017] Development of RNA aptamers specific for Japanese Encephalitis Virus (JEV) methytransferase
  • 학술발표[20081017] Cancer gene therapy by trans-splicing ribozyme-mediated RNA replacement in cancer cells
  • 학술발표[20081017] Tumor specific regression with KRasV12 transcript-replacing trans-splicing ribozyme
  • 학술발표[20081016] Deveolpment of aptazyme which activity is modulated by HCV protein
  • 학술발표[20081010] CKAP2 RNA-reprogramming trans-splicing ribozymes as specific and efficient cancer gene therapeutic agents
  • 학술발표[20081010] Development of specific cancer gene therapy using trans-splicing ribozyme that can specifically reprogram KRASV12 transcript
  • 학술발표[20081010] Development and characterization of allosteric ribozyme which activity can be specifically regulated by HCV NS5B protein.
  • 학술발표[20081010] Development of specific RNA-based cancer gene therapy using trans-splicing ribozyme
  • 학술발표[20081010] Riboswitch as controllable gene therapeutic agent
  • 학술발표[20081010] RNA aptamer as a new therapeutic agent against carcinoembryonic antigen inducing hepatic metastasis
  • 학술발표[20081010] Exogenously regulated allosteric trans-splicing ribozyme as target-specific and controllable gene therapeutic agent
  • 학술발표[20081010] In vitro selection of specific RNA aptamers to JEV methyltransferase
  • 학술발표[20081010] Development of controllable siRNA
  • 학술발표[20081009] Trans-splicing ribozyme for cancer therapy and molecular imaging.
  • 학술발표[20080711] RNA aptamer as an inhibitor against hepatic metastasis of colon cancer
  • 학술발표[20080711] Selective regression of K-RASV12-expressing tumor tissues using trans-splicing ribozyme
  • 학술발표[20080515] Artificial riboswitch to modulate HCV infection
  • 학술발표[20080117] Targeted and controllable RNA replacement with allosteric trans-splicing ribozyme as a new gene therapeutic approach
  • 학술발표[20071130] Exogenous control of targeted transgene expression with allosteric trans-splicing ribozyme
  • 학술발표[20071130] RNA aptamers against metastasis-related domain of CEA
  • 학술발표[20071130] Development of hTERT-targeting and theophylline-regulated allosteric trans-splicing ribozyme
  • 학술발표[20071130] Gene therapy against liver cancer through hepatocarcinoma-specific targeting using PEPCK promoter-driven trans-splicing ribozyme
  • 학술발표[20071130] Cancer gene therapy through targeted RNA replacement using KRASV12 RNA-targeting trans-splicing ribozyme
  • 학술발표[20071130] Development of allosteric hammerhead ribozyme which activity is controlled by HCV NS5B protein
  • 학술발표[20071018] Development of theophylline-regulated transplicing ribozyme which targets hTERT RNA
  • 학술발표[20071018] Development of RNA aptamers that can specifically bind to metastasis-related domain of carcinoembryonic antigen
  • 학술발표[20071018] Specific and efficient regression of hepatocarcinoma in vivo by Liver cancer-specific targeting with PEPCK promoter-driven trans-splicing ribozyme
  • 학술발표[20071018] Cancer Gene Therapy by Trans-Splicing Ribozyme-Mediated Targeted RNA Replacement
  • 학술발표[20071018] In vitro selection and characterization of aptazyme Which Activity is Modulated by HCV Protein
  • 학술발표[20071018] Specific regression of cancer cells via RNA replacement by KRASV12 transcript-targeting trans-splicing ribozyme
  • 학술발표[20071012] Targeted RNA replacement by Tetrahymena group I intron
  • 학술발표[20071004] RNA aptamers specific to metastasis-stimulating domain of carcinoembryonic antigen
  • 학술발표[20071004] hTERT-targeting trans-splicing ribozyme as potent anti-cancer agent
  • 학술발표[20071004] Trans-splicing ribozyme that can specifically regress cancer cells expressing K-RASV12
  • 학술발표[20071004] HCV-targeting allosteric ribozyme which activity is modulated by HCV protein
  • 학술발표[20070914] Liver cancer-specific targeting with PEPCK promoter-driven trans-splicing ribozyme
  • 학술발표[20070914] Identification and characterization of RNA aptamers to metastasis-related domain of carcinoembryonic antigen
  • 학술발표[20070602] Specific and efficient regression of hepatocarcinoma in vivo by liver-specific expression of hTERT-targeting trans-splicing ribozyme.
  • 학술발표[20070601] Development of RNA aptamer for human toll-like receptor 2.
  • 학술발표[20070530] Engineered allosteric ribozyme which activity is regulated by specific protein aptamer
  • 학술발표[20070530] Targeted regression of liver cancer cells by specific replacement of AFP RNA
  • 학술발표[20070527] New liver cancer gene therapy using tissue-specifically targeted RNA replacement
  • 학술발표[20070427] Trans-splicing ribozyme as emerging agent for cancer gene therapy
  • 학술발표[20070426] Anti-tumor effect and prolonged survival of cololectal liver metastasis with ribozyme-mediated cancer targeted gene therapy via systemic administration
  • 학술발표[20070419] RNA aptamers as emerging agents against hepatitis C virus replication
  • 학술발표[20070227] Allosteric HCV-targeting ribozyme which activity can be modulated by specific RNA aptamer
  • 학술발표[20061201] New gene therapeutic approach to hepatocarcinoma using trans-splicing ribozyme
  • 학술발표[20061111] Specific cancer gene therapy by tissue-specifically targeted RNA replacement
  • 학술발표[20061020] Targeted RNA Replacement by trans-splicing ribozyme as specific and efficient cancer gene therapy
  • 학술발표[20061020] Selective regression of cancer via tissue-specific expression of hTERT-targeting trans-splicing ribozyme
  • 학술발표[20061020] Development and characterization of RNA aptamer specific for carcinoembryonic antigen
  • 학술발표[20061012] Hepatocarcinoma-selective cancer regression by liver-specific expression of targeted trans-splicing ribozyme
  • 학술발표[20061012] Selective retardation of cells expressing mouse CKAP2 transcript by targeted trans-splicing ribozyme
  • 학술발표[20061012] Cancer gene therapy by trans-splicing ribozyme-mediated targeted RNA replacement selectively in cancer cells
  • 학술발표[20061012] Development of HCV-targeting hammerhead ribozyme which activity can be allosterically regulated by specific RNA aptamer
  • 학술발표[20061012] High affinity RNA aptamers to active prostate specific antigen
  • 학술발표[20060921] RNA aptamers specific to metastasis-promoting domain of carcinoembryonic antigen
  • 학술발표[20060921] Cancer gene therapy through trans-splicing ribozyme-mediated targeted and functional modification of hTERT transcript in a tissue-specific manner
  • 학술발표[20060921] Development of cancer gene therapy with trans-splicing ribozyme that can specifically replace K-RASV12 transcripts
  • 학술발표[20060619] RNA-based specific cancer therapy via tissue-specific expression of selectively cytotoxin-inducing trans-splicing ribozyme
  • 학술발표[20060602] Specific cancer regression by trans-splicing ribozyme-mediated replacement of K-RASV12 transcript
  • 학술발표[20060217] RNA-based molecular medicine
  • 학술발표[20060217] Aptamers for antiviral agents as decoys
  • 학술발표[20051209] Reprogramming gene expression by trans-splicing ribozyme: Application to specific and efficient cancer gene therapy
  • 학술발표[20051029] Modulation of hepatitis C virus multiplication by specific RNA aptamers against NS5B RNA replicase
  • 학술발표[20051018] Identification of carcinoembryonic antigen specific aptamer
  • 학술발표[20051018] In vitro selection of RNA aptamers that specifically bind human Alpha-fetoprotein
  • 학술발표[20051018] New cancer gene therapy with trans-splicing ribozyme-mediated targeted replacement of hTERT RNA
  • 학술발표[20051018] Development of cancer gene therapy with trans-splicing ribozymes that reprogram cancer specific CKAP2 transcripts
  • 학술발표[20051018] In vitro selection of high affinity RNA aptamers to prostate specific antigen
  • 학술발표[20051018] Development of trans-splicing ribozyme that specifically targets K-ras point mutated transcript
  • 학술발표[20050908] Trans-splicing ribozyme-mediated targeted and functional modification of specific transcript
  • 학술발표[20050908] RNA aptamers as emerging specific ligands for proteomics analysis
  • 학술발표[20050604] Inhibition of hepatitis C virus replication by in vitro selected specific RNA aptamers
  • 학술발표[20050602] Efficacy of group I intron-based trans-splicing ribozyme in tumor-targeted gene therapy
  • 학술발표[20050520] RNA aptamer-mediated modulation of hepatitis C Virus replication
  • 학술발표[20050520] Efficacy of tumor-targeted trans-splicing ribozyme
  • 학술발표[20041029] Tumor-targeted gene therapy by trans-splicing ribozyme reduced hepatotoxicity in mouse metastatic cancer model
  • 학술발표[20041022] Inhibition of HCV replication by in vitro selected RNA aptamers
  • 학술발표[20040918] Characterizaton and application of in vitro selected RNA aptamers
  • 학술발표[20040817] Trans-splicing ribozyme as a functional modifier of specific message
  • 학술발표[20040817] RNA aptamers as specific and high-affinity ligands
  • 학술발표[20040709] Specific cancer gene therapy by targeted trans-splicing ribozyme
  • 학술발표[20040603] Specific cancer cell regression by targeted trans-splicing ribozyme.
  • 학술발표[20040602] Inhibition of hepatitis C virus replication by specific RNA aptamers.
  • 학술발표[20040528] Modulation of hepatitis C virus replicon replication by specific RNA aptamers.
  • 학술발표[20040528] Specific cancer gene therapy with tissue-specific expression of targeted trans-splicing ribozyme.
  • 학술발표[20040528] Trans-splicing ribozyme specifically targeted to hTERT as a specific modulator of cancer cell survival.
  • 학술발표[20040527] Tumor regression by trans-splicing ribozyme.
  • 학술발표[20040520] Trans-splicing ribozyme as a new tool for cancer gene therapy
  • 학술발표[20031116] Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme
  • 학술발표[20030928] Trans-splicing ribozyme for cancer gene therapy
  • 학술발표[20030711] A new role of ribozyme: Target specific induction of therapeutic new gene activity by trans-splicing
  • 학술발표[20030711] Development of cancer gene therapy with trans-splicing ribozyme that can induce cytotoxin specifically in cancer cells
  • 학술발표[20030711] Affinity chromatography using photolabile beads linked RNA aptamer in a chip: Hepatitis C virus (HCV) polymerase detection.
  • 학술발표[20030703] Specificity of group I intron-based trans-splicing ribozyme that can selectively induce new gene activities in target RNA-expressing cells
  • 학술발표[20021107] Trans-splicing ribozymes as specific and selective delivers of therapeutic new gene activities
  • 학술발표[20021018] Deveopment of cancer gene therapy with trans-splicing ribozyme that specifically targets PD-ECGF transcripts.
  • 학술발표[20021018] Selection RNA aptamers that act as both inhibitors and templates of HCV NS5B RNA-dependent RNA polymerase.
  • 학술발표[20021018] Deveopment of cancer gene therapy with ribozyme that can induce cytotoxin specifically in cancer cells.
  • 학술발표[20021017] High-affinity RNA aptamers of NFATp.
  • 학술발표[20020825] Trans-splicing ribozymes that could induce therapeutic gene activities in hepatitis C virus infected cells
  • 학술발표[20020606] Ribozyme-triggered selective induction of cytotoxin in cancer cells by targeted trans-splicing
  • 학술발표[20011011] Ribozyme-Mediated Induction of Wild-Type p53 Activity in Mutant p53-Related Cancer Cells
  • 학술발표[20011011] Ribozyme-Mediated Selective Induction of Cytotoxin in Cancer Cells by Targeted Trans-Splicing.
  • 학술발표[20011011] In Vitro Selection of Potent RNA Aptamers That Inhibit HCV NS5B RNA-Dependent RNA Polymerase.
  • 학술발표[20011011] Ribozyme-Mediated Selective Induction of New Gene Activities in HCV IRES-Expressing Cells by Targeted Trans-Splicing.
  • 학술발표[20011011] Development of Cancer Gene Therapy with Trans-Splicing Ribozyme Targeted to Cancer Specific Telomerase.
  • 학술발표[20010531] Ribozyme-mediated selective induction of new gene activities in cancer cells by targeted trans-splicing
  • 학술발표[20010518] Ribozyme-mediated selective induction of new gene activities in specific cells by targeted trans-splicing.
  • 학술발표[20001206] Isolation of high affinity RNA aptamers specific for HCV regulatory proteins and their application for in situ diagnosis of the HCV proteins.
  • 학술발표[20001013] Development of trans-splicing ribozyme that specifically reprogram targeted HCV RNA.
  • 학술발표[20001013] In vitro selected RNA aptamers as specific diagnostic agents for in situ detection of HCV NS3 proteins.
  • 학술발표[20001012] In vitro selection of high affinity RNA aptamers to HCV NS5B RNA-dependent RNA polymerase.
  • 학술발표[20001012] Development of trans-splicing ribozyme that specifically target and reprogram cancer specific telomerase.
  • 학술발표[20000519] In vitro selection of potent RNA inhibitors of NFAT.
  • 학술발표[20000518] Development of therapeutic or diagnostic agents using RNA aptamers selected in vitro.
  • 학술발표[20000428] Molecular-genetic indices of gastric cancer.
  • 학술발표[19991119] Development of RNA-based molecular therapeutics
  • 학술발표[19991026] In vitro selection of high-affinity RNA ligands to NFAT from a random pool
  • 학술발표[19991025] Isolation of high-affinity RNA ligands to hnRNP L which is a cellular factoe for HCV IRES-mediated translation
  • 학술발표[19991025] Development and analysis of trans-splicing ribozymes to repair mutant transcripts which cause genetic diseases
  • 학술발표[19991025] Development of trans-splicing ribozyme targeted to the tumor suppresspr gene
  • 학술발표[19991025] In vitro selection of potent RNA decoys that inhibit HCV RNA helicase
  • 학술발표[19991025] In vitro selected RNA aptamer specifically binds to sialyl lewis X sugar moiety and inhibits selectin/ligand adsprption of HL60 cells
  • 학술발표[19991010] Selection of potent RNA decoys that inhibit HCV RNA helicase
  • 학술발표[19981201] Oligonucleotide Library를 사용한 특이성 리간드 개발
  • 학술발표[19981024] Isolation of High Affinity RNA Ligands to HCV Helicase from a Random Pool
  • 학술발표[19981024] Development of Trans-splicing Ribozyme for the gene therapy of Genetic Diseases
  • 학술발표[19980904] Development of Specific Ligands Using Oligonucleotide Library
  • 학술발표[19980823] Oligonucleotide LIbrary
  • 학술발표[19980611] Development of in vitro selection of specific RNA ligands from oligonucleotide combinatorial library
  • 학술발표[19980124] Ribozyme-mediated repair of mutant RNAs
  • 학술발표[19980122] Ribozyme-mediated repair of sickle beta-globin transcripts
  • 학술발표[19971018] In vitro selection of nuclease-resistant decoy RNAs that inhibit autoantibody functions
  • 학술발표[19970418] Inhibition of HIV with intracellularly expressed RNA decoys
  • 학술발표[19960601] Isolation of a nuclease resistant decoy RNA that can protect lymphocytes from autoantibodies directed against the human insulin receptors
  • 학술발표[19960528] Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells
  • 학술발표[19940925] Inhibition of HIV with intracelluarly expressed RNA decoys
  • 학술발표[19930204] Intracellular Immunization against HIV using RNA decoys
  • 학술발표[19861213] Studies on replication preocess of the parvovirus KBSH in embryonic swine kidney cells
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